The Aβ1–42/Aβ1–40 ratio in CSF is more strongly associated to tau markers and clinical progression than Aβ1–42 alone

被引：0
|
作者：
Constance Delaby
Teresa Estellés
Nuole Zhu
Javier Arranz
Isabel Barroeta
María Carmona-Iragui
Ignacio Illán-Gala
Miguel Ángel Santos-Santos
Miren Altuna
Isabel Sala
M. Belén Sánchez-Saudinós
Laura Videla
Sílvia Valldeneu
Andrea Subirana
Mireia Tondo
Francisco Blanco-Vaca
Sylvain Lehmann
Olivia Belbin
Rafael Blesa
Juan Fortea
Alberto Lleó
Daniel Alcolea
机构：
[1] Institut d’Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau,Sant Pau Memory Unit, Department of Neurology
[2] Universitat Autònoma de Barcelona,Servei de Bioquímica i Biologia Molecular
[3] IRMB,undefined
[4] INM,undefined
[5] Université de Montpellier,undefined
[6] INSERM,undefined
[7] CHU de Montpellier,undefined
[8] Laboratoire de Biochimie-Protéomique clinique,undefined
[9] Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas,undefined
[10] CIBERNED,undefined
[11] Fundació Catalana Síndrome de Down,undefined
[12] Centre Mèdic Down,undefined
[13] Servei de Bioquímica,undefined
[14] Institut d’Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau,undefined
[15] Universitat Autònoma de Barcelona,undefined
[16] Unversitat Autònoma de Barcelona,undefined
[17] Centro de Investigación Biomédica en Red en Diabetes y Enfermedades Metabólicas (CIBERDEM),undefined
来源：
Alzheimer's Research & Therapy | / 14卷
关键词：
Amyloid; Aβ1–40; Aβ1–42; Cerebrospinal fluid; Tau; Biomarkers;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Study of plasma levels of Aβ1-42, Aβ1-40, and p-tau in Alzheimer disease
    Peng, D
    Cai, X
    Xu, X
    Wang, X
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2005, 76 (04): : 614 - 615
  • [32] Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation
    Katarzyna Marta Zoltowska
    Masato Maesako
    Oksana Berezovska
    Molecular Medicine, 2016, 22 : 329 - 337
  • [33] Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation
    Zoltowska, Katarzyna Marta
    Maesako, Masato
    Berezovska, Oksana
    MOLECULAR MEDICINE, 2016, 22 : 329 - 337
  • [34] Is plasma amyloid-β 1-42/1-40 a better biomarker for Alzheimer's disease than AβX-42/X-40?
    Klafki, Hans-Wolfgang
    Morgado, Barbara
    Wirths, Oliver
    Jahn, Olaf
    Bauer, Chris
    Esselmann, Hermann
    Schuchhardt, Johannes
    Wiltfang, Jens
    FLUIDS AND BARRIERS OF THE CNS, 2022, 19 (01)
  • [35] CSF A1-42, but not p-Tau181, Predicted Progression from Amnestic MCI to Alzheimer's Disease Dementia
    Rizzi, Liara
    Missiaggia, Luciane
    Roriz-Cruz, Matheus
    NEUROMOLECULAR MEDICINE, 2018, 20 (04) : 491 - 497
  • [36] Levels of CSF-tau and amyloid beta(1-42) in frontotemporal lobar degeneration: Correlation with clinical and imaging characteristics
    Pijnenburg, YA
    NEUROBIOLOGY OF AGING, 2004, 25 : S455 - S455
  • [37] The free plasma amyloid A β 1-42 /A β 1-40 ratio predicts conversion to dementia for subjects with mild cognitive impairment with performance equivalent to that of the total plasma A β 1-42 /A β 1-40 ratio. The BALTAZAR study
    Schraen-Maschke, S.
    Duhamel, A.
    Vidal, J. S.
    Ramdane, N.
    Vaudran, L.
    Dussart, C.
    Buee, L.
    Sablonniere, B.
    Delaby, C.
    Allinquant, B.
    Gabelle, A.
    Bombois, S.
    Lehmann, S.
    Hanon, O.
    NEUROBIOLOGY OF DISEASE, 2024, 193
  • [38] Performance of Aβ1-40, Aβ1-42, Total Tau, and Phosphorylated Tau as Predictors of Dementia in a Cohort of Patients with Mild Cognitive Impairment
    Parnetti, Lucilla
    Chiasserini, Davide
    Eusebi, Paolo
    Giannandrea, David
    Bellomo, Gianni
    De Carlo, Claudia
    Padiglioni, Chiara
    Mastrocola, Sara
    Lisetti, Viviana
    Calabresi, Paolo
    JOURNAL OF ALZHEIMERS DISEASE, 2012, 29 (01) : 229 - 238
  • [39] Ratio Aβ1-42:p-Tau: a Possible Diagnostic Tool in Differentiating Dementias
    De Riva, Valentina
    Galloni, Elisabetta
    Lealini, Barbara
    Zarantonello, Giulia
    Disco, Caterina
    Di Dionisio, Laura
    Meligrana, Lucia
    Marcon, Michela
    Perini, Francesco
    CLINICAL LABORATORY, 2019, 65 (05) : 817 - 821
  • [40] Development of a specific diagnostic test for measurement of β-amyloid (1-42) [βA4(1-42)] in CSF
    Vanderstichele, H
    Blennow, K
    D'Heuvaert, N
    Buyse, MA
    Wallin, A
    Andreasen, N
    Seubert, P
    Van de Voorde, A
    Vanmechelen, E
    PROGRESS IN ALZHEIMER'S AND PARKINSON'S DISEASES, 1998, 49 : 773 - 778
12345