The anthelmintic efficacy and the safety of a combination of imidacloprid and moxidectin spot-on in cats and dogs under field conditions in Europe

Cats and dogs were allocated in veterinary practices located in three regions of Germany and in two regions of France. Fecal samples of 1,292 cats and 1,355 dogs were examined for the presence of nematode eggs. 141 positive cats and 131 positive dogs were treated with the test product or an established positive reference product: for cats a spot on combination of 10.0 mg/kg Imidacloprid and 1.0 mg/kg Moxidectin or 5 mg/kg Praziquantel and 57.5 mg/kg Pyrantelembonat, administered orally; for dogs a spot on combination of 10.0 mg/kg Imidacloprid and 2.5 mg/kg Moxidectin or 5.0 mg/kg Praziquantel, 14.4 mg/kg Pyrantelembonat and 15 mg Febantel, administered orally. Efficacy was assessed by analyzing the reduction in fecal egg counts of a fecal sample taken between days 7 to 1 before treatment in comparison to a fecal sample taken between days 7 to 13 after treatment. In cats, for the test product an efficacy of 99.99 % against Toxocara cati and an efficacy of 99.64 % against Ancylostomatidae was calculated. For the reference product an efficacy of 99.96 % and 100 % respectively was calculated. In dogs, for the test product an efficacy of 98.81 % against Toxocara canis and an efficacy of 99.92 against Ancylostomatidae was calculated. For the reference product an efficacy of 99.96 % and 99.91 respectively were calculated. In no cat or dog treated with the spot on combination of Imidacloprid and Moxidectin any adverse drug reaction was observed.