Conversion of D-carnitine into L-carnitine with stereospecific carnitine dehydrogenases

被引：0
|
作者：
Henning Hanschmann
Hans-Peter Kleber
机构：
[1] Universität Leipzig,Institut für Biochemie, Fakultät für Biowissenschaften, Pharmazie und Psychologie
来源：
Biotechnology Letters | 1997年 / 19卷
关键词：
Organic Chemistry; NADH; Carnitine; Agrobacterium; Permeabilized Cell;
D O I：
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中图分类号：
学科分类号：
摘要：
D-Carnitine was converted to L-carnitine by resting and permeabilized cells as well as with purified stereospecific carnitine dehydrogenases from Agrobacterium sp. With permeabilized cells only 11% of D-carnitine was converted into L-carnitine. Using highly stereospecific D- and L-carnitine dehydrogenases from Agrobacterium sp. (pH 8.5, 50 mM D-carnitine, 1 mM NAD + , 0.1 mM NADH, 25-fold excess of L-carnitine dehydrogenase) almost 50% of the D-carnitine could be converted into L-carnitine.
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页码：679 / 682
页数：3
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