Blocking siglec-10hi tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma

被引：0
|
作者：
Nan Xiao
Xiaodong Zhu
Kangshuai Li
Yifan Chen
Xuefeng Liu
Bin Xu
Ming Lei
Jiejie Xu
Hui-Chuan Sun
机构：
[1] Liver Cancer Institute and Zhongshan Hospital,Department of Liver Surgery and Transplantation
[2] Fudan University,Department of Hepatobiliary Surgery
[3] Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University),Department of Immunology, School of Basic Medical Sciences
[4] Ministry of Education,Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences
[5] Qilu Hospital of Shandong University,undefined
[6] Fudan University,undefined
[7] Fudan University,undefined
来源：
Experimental Hematology & Oncology | / 10卷
关键词：
Macrophages; Tumor microenvironment; Hepatocellular carcinoma; Immunotherapy; Immune evasion;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Integrin agonists reduce infiltration of tumor-associated macrophages to promote T-cell mediated anti-tumor immunity
    Khan, Samia Q.
    Faridi, Mohd. H.
    Khaliqdina, Shehryar J.
    Barbosa, Antonio J.
    Varner, Judith A.
    Gupta, Vineet
    CANCER IMMUNOLOGY RESEARCH, 2017, 5 (03)
  • [32] Deletion of the RNA regulator HuR in tumor-associated microglia and macrophages stimulates anti-tumor immunity and attenuates glioma growth
    Wang, Jiping
    Leavenworth, Jianmei W.
    Hjelmeland, Anita B.
    Smith, Reed
    Patel, Neha
    Borg, Ben
    Si, Ying
    King, Peter H.
    GLIA, 2019, 67 (12) : 2424 - 2439
  • [33] Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis
    Yau-tuen Chan
    Hor-yue Tan
    Yuanjun Lu
    Cheng Zhang
    Chien-shan Cheng
    Junyu Wu
    Ning Wang
    Yibin Feng
    Acta Pharmaceutica Sinica B, 2023, (04) : 1554 - 1567
  • [34] Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis
    Chan, Yau-tuen
    Tan, Hor-yue
    Lu, Yuanjun
    Zhang, Cheng
    Cheng, Chien-shan
    Wu, Junyu
    Wang, Ning
    Feng, Yibin
    ACTA PHARMACEUTICA SINICA B, 2023, 13 (04) : 1554 - 1567
  • [35] Systemic dendrimer delivery of triptolide to tumor-associated macrophages improves anti-tumor efficacy and reduces systemic toxicity in glioblastoma
    Liaw, Kevin
    Sharma, Rishi
    Sharma, Anjali
    Salazar, Sebastian
    Appiani La Rosa, Santiago
    Kannan, Rangaramanujam M.
    Journal of Controlled Release, 2021, 329 : 434 - 444
  • [36] Systemic dendrimer delivery of triptolide to tumor-associated macrophages improves anti-tumor efficacy and reduces systemic toxicity in glioblastoma
    Liaw, Kevin
    Sharma, Rishi
    Sharma, Anjali
    Salazar, Sebastian
    La Rosa, Santiago Appiani
    Kannan, Rangaramanujam M.
    JOURNAL OF CONTROLLED RELEASE, 2021, 329 : 434 - 444
  • [37] Interaction between tumor-associated macrophages and tumor endothelial cells in hepatocellular carcinoma.
    Matoba, Daijiro
    Noda, Takehiro
    Kobayashi, Shogo
    Sasaki, Kazuki
    Iwagami, Yoshifumi
    Yamada, Daisaku
    Tomimaru, Yoshito
    Takahashi, Hidenori
    Wada, Hisashi
    Doki, Yuichiro
    Eguchi, Hidetoshi
    CANCER SCIENCE, 2024, 115 : 1915 - 1915
  • [38] Tumor-associated macrophages activated in the tumor environment of hepatocellular carcinoma: Characterization and treatment (Review)
    Yu, Mingkai
    Yu, Haixia
    Wang, Hongmei
    Xu, Xiaoya
    Sun, Zhaoqing
    Chen, Wenshuai
    Yu, Miaomiao
    Liu, Chunhua
    Jiang, Mingchun
    Zhang, Xiaowei
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2024, 65 (04)
  • [39] Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages
    Shu, Yuxin
    Yang, Nanfei
    Cheng, Nan
    Zou, Zhengyun
    Zhang, Wenlong
    Bei, Yuncheng
    Shi, Qian
    Qin, Menghao
    Zhu, Wei-Guo
    Shen, Pingping
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022, 7 (01)
  • [40] Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages
    Yuxin Shu
    Nanfei Yang
    Nan Cheng
    Zhengyun Zou
    Wenlong Zhang
    Yuncheng Bei
    Qian Shi
    Menghao Qin
    Wei-Guo Zhu
    Pingping Shen
    Signal Transduction and Targeted Therapy, 7
12345