Acute vasomotor paralysis and potential downstream effects of paclitaxel from stents implanted for saphenous vein aorto-coronary bypass stenosis

被引:0
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作者
Petra Kleinbongard
Dirk Böse
Thomas Konorza
Florian Steinhilber
Stefan Möhlenkamp
Holger Eggebrecht
Theodor Baars
Hubertus Degen
Michael Haude
Bodo Levkau
Raimund Erbel
Gerd Heusch
机构
[1] Universitätsklinikum Essen,Institut für Pathophysiologie
[2] Universitätsklinikum Essen,Klinik für Kardiologie
[3] Städtische Kliniken Neuss,undefined
[4] Lukaskrankenhaus GmbH,undefined
来源
Basic Research in Cardiology | 2011年 / 106卷
关键词
Coronary disease; Stents; Vasoconstriction; Vasodilation;
D O I
暂无
中图分类号
学科分类号
摘要
Implantation of bare metal stents (BMS) induces the release not only of particulate debris, but also of soluble vasoconstrictors which contribute to microvascular impairment. So this study aimed at addressing the potential attenuation of such vasoconstriction using paclitaxel eluting stents (PES). Using a distal protection/aspiration device, coronary arterial blood was retrieved before and during stent [n = 14 BMS, n = 14 PES, n = 3 sirolimus eluting stents (SES)] implantation in patients with saphenous vein aorto-coronary bypass stenosis and analyzed for plasma serotonin and thromboxane B2 concentrations. The vasoconstriction of rat mesenteric arteries with intact (+E) and denuded (−E) endothelium in response to coronary arterial or aspirate plasma was quantified and normalized to that by potassium chloride (KClmax = 100%). Coronary arterial plasma before stent implantation induced a vasoconstriction of 30–43%, which was independent of endothelial integrity. Serotonin-release was 2.2 ± 0.5 μmol/l with BMS and 2.0 ± 0.4 μmol/l with PES, thromboxane B2-release was 26 ± 5 pg/ml with BMS and 22 ± 8 pg/ml with PES. BMS- and SES-aspirate plasma induced a vasoconstriction of 68 ± 18% (+E)/93 ± 14% (−E) and 81 ± 17% (+E)/124 ± 14% (−E), respectively. In contrast, PES-aspirate plasma induced only minor vasoconstriction of 8 ± 3% (+E)/12 ± 5% (−E). Addition of paclitaxel to BMS-aspirate plasma attenuated vasoconstriction. PES-aspirate induced microtubular condensation in immunofluorescence microscopy. Results indicate that aspirate from PES implantation attenuates vasoconstriction, possibly secondary to microtubular stabilization. Such acute downstream vascular paralysis could be beneficial in preventing a no-reflow phenomenon in patients undergoing stenting.
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页码:681 / 689
页数:8
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