NMDA receptor signaling induces the chemoresistance of temozolomide via upregulation of MGMT expression in glioblastoma cells

被引：0
|
作者：
Shohei Tsuji
Shinsuke Nakamura
Kenji Shoda
Tetsuya Yamada
Masamitsu Shimazawa
Noriyuki Nakayama
Toru Iwama
Hideaki Hara
机构：
[1] Gifu Pharmaceutical University,Molecular Pharmacology, Department of Biofunctional Evaluation
[2] Gifu University Graduate School of Medicine,Department of Neurosurgery
[3] Gifu Pharmaceutical University,Lab. Of Collaborative Research for Innovative Drug Discovery
来源：
Journal of Neuro-Oncology | 2022年 / 160卷
关键词：
-methyl-D-aspartate receptor; Glioblastoma; O; -methylguanine DNA methyltransferase; Memantine; Temozolomide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：375 / 388
页数：13
相关论文
共 50 条
  • [41] Aberrant Expression of ADARB1 Facilitates Temozolomide Chemoresistance and Immune Infiltration in Glioblastoma
    Lu, Can
    Chen, Xi
    Yan, Yuanliang
    Ren, Xinxin
    Wang, Xiang
    Peng, Bi
    Cai, Yuan
    Liang, Qiuju
    Xu, Zhijie
    Peng, Jinwu
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [42] Blocking MAPK/ERK pathway sensitizes hepatocellular carcinoma cells to temozolomide via downregulating MGMT expression
    Li, Qiang
    Ren, Bingjie
    Gui, Qi
    Zhao, Jing
    Wu, Mengyao
    Shen, Meng
    Li, Dapeng
    Li, Daoming
    Chen, Kai
    Tao, Min
    Liang, Rongrui
    ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8 (20)
  • [43] EXPRESSION OF NDRG2 SENSITIZES GLIOBLASTOMA CELLS TO TEMOZOLOMIDE VIA Akt INACTIVATION
    Takeshima, Hideo
    Yamashita, Shinji
    Yokogami, Kiyotaka
    Mizuguchi, Souhei
    Nakamura, Hideo
    Kuratsu, Junichi
    Fukushima, Tsuyoshi
    Morishita, Kazuhiro
    NEURO-ONCOLOGY, 2013, 15 : 27 - 28
  • [44] MEK-ERK Signaling Dictates DNA-Repair Gene MGMT Expression and Temozolomide Resistance of Stem-Like Glioblastoma Cells via the MDM2-p53 Axis
    Sato, Atsushi
    Sunayama, Jun
    Matsuda, Ken-ichiro
    Seino, Shizuka
    Suzuki, Kaori
    Watanabe, Eriko
    Tachibana, Ken
    Tomiyama, Arata
    Kayama, Takamasa
    Kitanaka, Chifumi
    STEM CELLS, 2011, 29 (12) : 1942 - 1951
  • [45] Combined silencing expression of MGMT with EGFR or galectin-1 enhances the sensitivity of glioblastoma to temozolomide
    Messaoudi, Khaled
    Clavreul, Anne
    Danhier, Fabienne
    Saulnier, Patrick
    Benoit, Jean-Pierre
    Lagarce, Frederic
    EUROPEAN JOURNAL OF NANOMEDICINE, 2015, 7 (02) : 97 - 107
  • [46] Temozolomide resistance in human glioblastoma is associated with marked increase in PDK1 and MGMT expression
    Lee, William
    Velpula, Kiran Kumar
    Tsung, Andrew J.
    CANCER RESEARCH, 2014, 74 (19)
  • [47] Chemoresistance to doxorubicin induces epithelial-mesenchymal transition via upregulation of transforming growth factor signaling in HCT116 colon cancer cells
    Li, Jinpeng
    Liu, Hao
    Yu, Jieping
    Yu, Honggang
    MOLECULAR MEDICINE REPORTS, 2015, 12 (01) : 192 - 198
  • [48] FoxO3a induces temozolomide resistance in glioblastoma cells via the regulation of β-catenin nuclear accumulation
    Xu, Ke
    Zhang, Zhenhao
    Pei, Hua
    Wang, Huamin
    Li, Liang
    Xia, Qianfeng
    ONCOLOGY REPORTS, 2017, 37 (04) : 2391 - 2397
  • [49] LOSS OF WILLIAMS SYNDROME TRANSCRIPTION FACTOR (WSTF) LEADS TO IMPROVED TEMOZOLOMIDE SENSITIVITY IN HUMAN GLIOBLASTOMA CELLS IRRESPECTIVE OF MGMT EXPRESSION
    Sarnow, Katharina
    Schwab, Stephanie
    Rio, Oline
    Mukherjee, Joydeep
    Bjerkvig, Rolf
    Johannessen, Tor-Christian
    NEURO-ONCOLOGY, 2021, 23 : 30 - 30
  • [50] LOSS OF WILLIAMS SYNDROME TRANSCRIPTION FACTOR (WSTF) LEADS TO IMPROVED TEMOZOLOMIDE SENSITIVITY IN HUMAN GLIOBLASTOMA CELLS IRRESPECTIVE OF MGMT EXPRESSION
    Sarnow, K.
    Schwab, S. G.
    Rio, O.
    Mukherjee, J.
    Bjerkvig, R.
    Johannessen, T. A.
    NEURO-ONCOLOGY, 2021, 23 : 56 - 56
12345