Angiotensin I-converting enzyme polymorphisms, ACE level and blood pressure among Nigerians, Jamaicans and African-Americans

被引:0
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作者
Nourdine Bouzekri
Xiaofeng Zhu
Yanming Jiang
Colin A McKenzie
Amy Luke
Terrence Forrester
Adebowale Adeyemo
Donghui Kan
Martin Farrall
Simon Anderson
Richard S Cooper
Ryk Ward
机构
[1] University of Oxford,Department of Biological Anthropology
[2] Loyola University Medical Center,Department of Preventive Medicine and Epidemiology
[3] Tropical Medicine Research Institute,Department of Pediatrics/Institute for Child Health
[4] University of the West Indies,Department of Cardiovascular Medicine
[5] College of Medicine,undefined
[6] University of Ibadan,undefined
[7] University of Oxford,undefined
[8] The Wellcome Trust Centre for Human Genetics,undefined
来源
European Journal of Human Genetics | 2004年 / 12卷
关键词
ACE; association; haplotype;
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学科分类号
摘要
The genes in the renin–angiotensin system are important physiologic candidates in studies of the genetic susceptibility to hypertension. Limited information has been available in most studies on the extent of variation in the candidate loci or the modifying effects of different environmental settings. We consequently genotyped 13 polymorphisms at the angiotensin I-converting enzyme (ACE) locus at an average distance of 2 kb in 2776 family members from Nigeria, Jamaica and an African-American community in the US. Allele and haplotype frequencies were similar in the three populations, with modest evidence of European admixture in the US. Two markers were consistently associated with ACE level in the three samples and the proportion of variance accounted for by ACE8 was similar in the three groups. No evidence of consistent association of single markers was noted with blood pressure across the three population samples, however. Likewise, in a haplotype-based analysis, despite significant associations within each population, the findings were not replicated consistently across all three samples. We did observe, however, that the overtransmitted haplotypes among hypertensives were drawn from a single clade, suggesting that susceptibility may cluster in patterns not captured directly by our markers.
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页码:460 / 468
页数:8
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