Kinetic-spectrophotometric determination of neomycin

被引：1
|
作者：
I. D. Rašić Mišić
G. Ž. Miletić
S. S. Mitić
D. A. Kostić
A. S. Djordjević
机构：
[1] University of Niš,Department of Chemistry, Faculty of Science and Mathematics
来源：
Journal of Analytical Chemistry | 2015年 / 70卷
关键词：
kinetics; UV-Vis spectrophotometry; modified Berthelot reaction; neomycin; ophthalmic drops;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new kinetically-based spectrophotometric method for the determination of micro quantities of neomycin is described in this paper. It is an adaptation of the modified Berthelot method which is a widely used colorimetric procedure for urea determination. The method was developed due to neomycin effect on 2,2′-dicarboxyindophenol formation. The experimental conditions for successful determination of neomycin were optimized. The relative standard deviation (RSD) for the neomycin concentration interval of 77–154 μg/mL, ranges from 0.7 to 1%. The method was directly applied to determining neomycin in ophthalmic drops. The obtained results in analyzed pharmaceutical samples were in accordance with disc-diffusion microbiological method results.
引用
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页码：234 / 239
页数：5
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