Targeting breast cancer stem cells: fishing season open!

被引：0
|
作者：
Christophe Ginestier
Emmanuelle Charafe-Jauffret
Daniel Birnbaum
机构：
[1] Laboratoire d'Oncologie Moléculaire,Centre de Recherche en Cancérologie de Marseille
[2] UMR891 Inserm/Institut Paoli-Calmettes,undefined
来源：
Breast Cancer Research | / 12卷
关键词：
Breast Cancer Cell Line; Cancer Stem Cell; Salinomycin; Light Cell; Human Breast Cancer Xenograft;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Studies describing the tumor as a hierarchically organized cell population have changed the classical oncogenesis view and propose new therapeutic strategies. Cancer stem cells (CSCs) are thought to sustain tumor initiation/maintenance, therapy resistance, and systemic metastases. Targeting this tumor cell population is crucial to achieve a true cancer cure. A large research effort is now aiming to develop drugs targeting CSCs, based either on a priori understanding of key pathways regulating CSC biology or on high-throughput screening to identify novel targets and compounds.
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