Spiroacetal substructures introduce important conformational constraints into bioactive polyketide natural products. New research reveals a two-enzyme team responsible for this molecular origami in reveromycin A biosynthesis.
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Univ East London, Sch Hlth Sports & Biosci, Med Microbiol, London, EnglandUniv East London, Sch Hlth Sports & Biosci, Med Microbiol, London, England
机构:
CUNY, Coll Staten Isl, Dept Math, Staten Isl, NY 10314 USA
CUNY, Grad Ctr, Dept Math, New York, NY 10016 USACUNY, Coll Staten Isl, Dept Math, Staten Isl, NY 10314 USA
Champanerkar, Abhijit
Kofman, Ilya
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CUNY, Coll Staten Isl, Dept Math, Staten Isl, NY 10314 USA
CUNY, Grad Ctr, Dept Math, New York, NY 10016 USACUNY, Coll Staten Isl, Dept Math, Staten Isl, NY 10314 USA