Diagnosis of disorders of platelet function by flow cytometry

被引：0
|
作者：
Hu Yu
Huang Ruibin
Chen Zhichao
Wei Wenning
机构：
[1] Tongji Medical University,Institute of Hematology, Xiehe Hospital
来源：
Current Medical Science | 1999年 / 19卷 / 2期
关键词：
flow cytometry; platelet membrane glycoprotein; Glannzmann’s thrombasthenia;
D O I：
10.1007/BF02886884
中图分类号：
学科分类号：
摘要：
The platelet membrane glycoprotein (GP) IIb/IIIa, GPIX were detected by immunogold assay and flow cytometry, respectively, in two cases of Glannzmann’s thrombasthenia (GT). The immunogold assay showed that the GP IIb/IIIa. gold granules in GT were decreased obviously, compared with that in normal controls. Flow cytometry results showed that GP IIb/ IIIa in two cases of GT was 0. 1 % and 0. 5% of normal control, respectively. While GPIX showed no difference between the GT and normal control. The patients’ father showed no bleeding symptoms, whose GP IIb/IIIa accounted for 36. 99% of normal control. The experiment results suggested that flow cytometry is a quick, simple and sensitive method for the diagnosis of GP disorders.
引用
收藏
页码：96 / 98
页数：2
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