LncRNA & Wnt signaling in colorectal cancer

被引：0

作者：

Zeeshan Javed

Khushbukhat Khan

Haleema Sadia

Shahid Raza

Bahare Salehi

Javad Sharifi-Rad

William C. Cho

机构：

[1] Office for Research Innovation and Commercialization,Atta

[2] Lahore Garrison University,ur

[3] National University of Sciences and Technology (NUST),Rahman School of Applied Biosciences (ASAB)

[4] Balochistan University of Information Technology,Department of Biotechnology

[5] Engineering and Management Sciences,Department of Biotechnology

[6] University of Central Punjab,Noncommunicable Diseases Research Center

[7] Bam University of Medical Sciences,Student Research Committee, School of Medicine

[8] Bam University of Medical Sciences,Department of Clinical Oncology

[9] Phytochemistry Research Center,undefined

[10] Shahid Beheshti University of Medical Sciences,undefined

[11] Queen Elizabeth Hospital,undefined

来源：

Cancer Cell International | / 20卷

关键词：

signaling; Colorectal cancer; lncRNA; Therapeutics strategy;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The outlook for new therapeutic approaches is pivotal to ameliorate the deterioration caused by the abrogated Wnt signaling. Long non-coding RNAs (lncRNAs) are tiny molecules that have begun emerging as vital molecular manager for the regulation of various cellular processes at transcription and translation levels in the colorectal cancer (CRC). Targeting Wnt pathway with lncRNA seems a promising approach to eradicate CRC. However, little is known of their active role in commencing both apoptosis and proliferation in CRC. This article reviews the importance of these molecules in the pathogenesis of CRC and also emphasizes on the development of new therapeutic strategies to cope with the Wnt mediated CRC.

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