The sea-ice cover of the Arctic Ocean is decreasing in areal extent and volume more rapidly than model predictions of its response to continued warming of earth’s lower atmosphere. Reflecting this decrease is the spatial and temporal widening of the circumpolar flaw lead, a zone of open water and unconsolidated ice along the coastlines of the shallow seas that surround the deep Arctic Ocean basins. As part of the International Polar Year, the Circumpolar Flaw Lead System Study deployed the research icebreaker Amundsen from October 2007 to August 2008 in the flaw lead segment bordering Banks Island in the Canadian Beaufort Sea. With participation from Canada, the USA, Spain, Germany, China, Russia, the UK, Norway, Belgium, the Netherlands, France, and Sweden, the multi-disciplinary overwintering expedition logged 9,812 scientist-days in an effort to decipher key aspects of the ecosystem of the flaw lead. Highlights of the scientific achievements documented in this special issue on the biology of the circumpolar flaw lead system help to capture the depth, breadth, and novelty of this remarkable exploration.