miR-125b Inhibits Connexin43 and Promotes Glioma Growth

被引：0
|
作者：
Zheng Jin
Songbai Xu
Hongquan Yu
Boyu Yang
Hongguang Zhao
Gang Zhao
机构：
[1] Jilin University,Department of Neurosurgery, The First Hospital
[2] Jilin University,Department of Radiology, The First Hospital
来源：
Cellular and Molecular Neurobiology | 2013年 / 33卷
关键词：
MicroRNA; Glioma; Connexin43; mRNA;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MicroRNA is strongly associated with tumor growth and development. This study examined the potential roles of miR-125b in glioma growth. We found that miR-125b promotes glioma cell line growth and clone formation, and protects the glioma cells from apoptosis in vitro. The miR-125b-transfected glioma cells also demonstrated increased growth after in vivo transplantation. We further identified that miR-125b inhibits Connexin43 expression, and the overexpression of Connexin43 antagonizes the effects of miR-125b in cell growth and anti-apoptosis. We conclude that miR-125b regulates glioma growth partly through Connexin43 protein.
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页码：1143 / 1148
页数：5
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