The Synthesis of (1,3,4-Oxadiazol-2-yl)Acrylic Acid Derivatives with Antibacterial and Protistocidal Activities

被引：0

作者：

L. D. Popov

A. A. Zubenko

L. N. Fetisov

Yu. D. Drobin

A. I. Klimenko

A. N. Bodryakov

S. A. Borodkin

I. E. Melkozerova

机构：

[1] Southern Federal University,Department of Chemistry

[2] North-Caucasian Zonal Scientific Research Veterinary Institute,undefined

[3] Don State Agrarian University,undefined

[4] Rostov-on-Don Basic Medical College,undefined

来源：

Russian Journal of Bioorganic Chemistry | 2018年 / 44卷

关键词：

acrylic acid; antibacterial activity; 1,3,4-oxadiazol; protistocidal activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of new 1,3,4-oxadiazol-2-yl-acrylic acids was synthesized by cyclization of 4-(2-R-hydrazino)- 4-oxo-2-butenic acids, and their antibacterial and protistocidal activities were studied. The p-substituted benzyl derivatives in the Z-form were shown to exhibit a high protistocidal activity, which exceeded that of the reference drug Baycox (toltrazuril) by several times, whereas the 3-hydroxy-2-naphthyl derivative, in addition to a very high protistocidal activity, also exhibited a moderate antibacterial activity.

引用

页码：238 / 243

页数：5

共 50 条

[21] Synthesis of novel nicotinohydrazide and (1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridine derivatives as potential anticancer agents
Kumar, R. Naresh
Poornachandra, Y.
Nagender, P.
Kumar, G. Santhosh
Swaroop, D. Krishna
Kumar, C. Ganesh
Narsaiah, B.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (19) : 4829 - 4831
[22] 2,6-Dimethyl-4-(1,3,4-oxadiazol-2-yl)quinoline
Kashaev, Artyom G.
Zimichev, Anatoliy V.
Rybakov, Victor B.
Klimochkin, Yurij N.
Zemtsova, Margarita N.
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O3333 - U2118
[23] Synthesis of a new series of 1,8-bis (5-mercapto 1,3,4-oxadiazol-2-yl) octane and their derivatives
Kudari, SM
Badiger, SE
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 1997, 7 (02) : 135 - 138
[24] Synthesis of some bis-(1,3,4-oxadiazol-2-yl) methanes of biological and pharmacological interest
Ranga, BV
Sangapure, SS
ASIAN JOURNAL OF CHEMISTRY, 1997, 9 (04) : 663 - 665
[25] Polymorphism of 3-(5-phenyl-1,3,4-oxadiazol-2-yl)- and 3-[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]-2H-chromen-2-ones
Shishkina, Svitlana V.
Konovalova, Irina S.
Trostianko, Pavlo V.
Geleverya, Anna O.
Kovalenko, Sergiy M.
Bunyatyan, Natalya D.
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2019, 75 : 1541 - +
[26] Synthesis and antitumor activity of oxazol-2-yl, benzoxazol-2-yl and 1,3,4-oxadiazol-2-yl sulfur ethers
Zhang, Cheng-Ren
Wang, Liu
Ge, Yan-Li
Ju, Xiu-Lian
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2007, 27 (11) : 1432 - 1437
[27] Synthesis and evaluation of the antimicrobial activities of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives
Liu, Jia-Chun
Zheng, Chang-Ji
Wang, Meng-Xiao
Li, Ya-Ru
Ma, Long-Xu
Hou, Shao-Pu
Piao, Hu-Ri
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 74 : 405 - 410
[28] Synthesis and in vitro activity of novel 2-(benzylthio)-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives
Kamil Brożewicz
Jarosław Sławiński
Monatshefte für Chemie - Chemical Monthly, 2012, 143 : 975 - 984
[29] Photochromic dihetarylethenes. 12.* Synthesis of 5-alkyl-2- (1,3,4-oxadiazol-2-yl)thiophenes and their photochromic derivatives
Krayushkin M.M.
Stoyanovich F.M.
Zolotarskaya O.Yu.
Chernoburova E.I.
Makhova N.N.
Yarovenko V.N.
Zavarzin I.V.
Martynkin A.Yu.
Uzhinov B.M.
Chemistry of Heterocyclic Compounds, 2002, 38 (02) : 165 - 176
[30] Synthesis and antibacterial activity of 5-(5'-substituted 1,3,4-oxadiazol-2'-yl) dihydropyrimidinone derivatives
Purohit, M. N.
Kunal, Chokshi
Pujar, G. V.
Mayur, Y. C.
Shantakumar, S. M.
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2007, 16 (04) : 349 - 352

← 1 2 3 4 5 →