Precision medicine for cancer with next-generation functional diagnostics

被引:0
|
作者
Adam A. Friedman
Anthony Letai
David E. Fisher
Keith T. Flaherty
机构
[1] Massachusetts General Hospital Cancer Center,
[2] Harvard Medical School,undefined
[3] Dermatology and Cutaneous Biology Research Center,undefined
[4] Massachusetts General Hospital,undefined
[5] Dana-Farber Cancer Institute,undefined
[6] Harvard Medical School,undefined
来源
Nature Reviews Cancer | 2015年 / 15卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Genome-based cancer therapeutic matching is limited by incomplete biological understanding of the relationship between phenotype and cancer genotype. This Opinion article proposes that this limitation can be addressed by functional testing of live patient tumour cells exposed to potential therapies.
引用
收藏
页码:747 / 756
页数:9
相关论文
共 50 条
  • [41] Next-generation confirmatory disease diagnostics
    Lin, Robert
    Gerver, Rachel
    Karns, Kelly
    Apori, Akwasi A.
    Denisin, Aleksandra K.
    Herr, Amy E.
    SENSING TECHNOLOGIES FOR GLOBAL HEALTH, MILITARY MEDICINE, AND ENVIRONMENTAL MONITORING IV, 2014, 9112
  • [42] Mobile diagnostics: next-generation technologies for in vitro diagnostics
    Shin, Joonchul
    Chakravarty, Sudesna
    Choi, Wooseok
    Lee, Kyungyeon
    Han, Dongsik
    Hwang, Hyundoo
    Choi, Jaekyu
    Jung, Hyo-Il
    ANALYST, 2018, 143 (07) : 1515 - 1525
  • [43] Next-generation academic medicine
    Brenner, David A.
    JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (11): : 4280 - 4282
  • [44] Toward precision medicine with next-generation EGFR inhibitors in non-small-cell lung cancer
    Yap, Timothy A.
    Popat, Sanjay
    PHARMACOGENOMICS & PERSONALIZED MEDICINE, 2014, 7 : 285 - 295
  • [45] Next-generation diagnostics for precision oncology: Preanalytical considerations, technical challenges, and available technologies
    Walter, Wencke
    Pfarr, Nicole
    Meggendorfer, Manja
    Jost, Philipp
    Haferlach, Torsten
    Weichert, Wilko
    SEMINARS IN CANCER BIOLOGY, 2022, 84 : 3 - 15
  • [46] Toward Next-Generation Phenomics: Precision Medicine, Spaceflight, Astronaut Omics, and Beyond
    Ozdemir, Vural
    OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2024, 28 (08) : 377 - 379
  • [47] An updated review of microsatellite instability in the era of next-generation sequencing and precision medicine
    Yamamoto, Hiroyuki
    Imai, Kohzoh
    SEMINARS IN ONCOLOGY, 2019, 46 (03) : 261 - 270
  • [48] Comparative analyses of error handling strategies for next-generation sequencing in precision medicine
    Hannah F. Löchel
    Dominik Heider
    Scientific Reports, 10
  • [49] Next generation sequencing in cancer: opportunities and challenges for precision cancer medicine
    Paolillo, Carmela
    Londin, Eric
    Fortina, Paolo
    SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2016, 76 : S84 - S91
  • [50] Mission critical: the need for proteomics in the era of next-generation sequencing and precision medicine
    Cayer, Devon M.
    Nazor, Kristopher L.
    Schork, Nicholas J.
    HUMAN MOLECULAR GENETICS, 2016, 25 (R2) : R182 - R189