Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

被引：0

作者：

Ly P Vu

Camila Prieto

Elianna M Amin

Sagar Chhangawala

Andrei Krivtsov

M Nieves Calvo-Vidal

Timothy Chou

Arthur Chow

Gerard Minuesa

Sun Mi Park

Trevor S Barlowe

James Taggart

Patrick Tivnan

Raquel P Deering

Lisa P Chu

Jeong-Ah Kwon

Cem Meydan

Javier Perales-Paton

Arora Arshi

Mithat Gönen

Christopher Famulare

Minal Patel

Elisabeth Paietta

Martin S Tallman

Yuheng Lu

Jacob Glass

Francine E Garret-Bakelman

Ari Melnick

Ross Levine

Fatima Al-Shahrour

Marcus Järås

Nir Hacohen

Alexia Hwang

Ralph Garippa

Christopher J Lengner

Scott A Armstrong

Leandro Cerchietti

Glenn S Cowley

David Root

John Doench

Christina Leslie

Benjamin L Ebert

Michael G Kharas

机构：

[1] Molecular Pharmacology Program,Department of Pediatric Oncology

[2] Center for Cell Engineering,Department of Medicine, Division of Hematology/Oncology

[3] Center for Stem Cell Biology,Division of Hematology

[4] and Center for Experimental Therapeutics,Department of Physiology and Biophysics

[5] Memorial Sloan Kettering Cancer Center,Department of Epidemiology and Biostatistics

[6] Physiology,Department of Medicine

[7] Biophysics and Systems Biology Graduate Program,Department of Medicine

[8] Weill Cornell Graduate School of Medical Sciences,Department of Medicine

[9] Cornell University,Department of Medicine and Department of Biochemistry and Molecular Genetics

[10] Computational Biology Program,Division of Hematology and Medical Oncology, Departments of Medicine and Pharmacology

[11] Memorial Sloan Kettering Cancer Center,Department of Clinical Genetics

[12] Cancer Biology and Genetics Program,Department of Animal Biology, Department of Cell and Developmental Biology

[13] Memorial Sloan Kettering Cancer Center,undefined

[14] Dana-Farber Cancer Institute,undefined

[15] Harvard Medical School,undefined

[16] Weill Cornell Medical College,undefined

[17] Harvard Medical School,undefined

[18] Brigham and Woman's Hospital,undefined

[19] Whitehead Institute,undefined

[20] Institute for Computational Biomedicine,undefined

[21] Weill Cornell Medical College,undefined

[22] Translational Bioinformatics Unit,undefined

[23] Clinical Research Programme,undefined

[24] Spanish National Cancer Research Centre,undefined

[25] Memorial Sloan Kettering Cancer Center,undefined

[26] Human Oncology and Pathogenesis Program,undefined

[27] Leukemia Service,undefined

[28] Memorial Sloan Kettering Cancer Center,undefined

[29] Montefiore Medical Center,undefined

[30] Leukemia Service,undefined

[31] Memorial Sloan Kettering Hospital,undefined

[32] University of Virginia,undefined

[33] Weill Cornell Medical College,undefined

[34] Cornell University,undefined

[35] Lund University,undefined

[36] RNAi Core,undefined

[37] Memorial Sloan Kettering Cancer Center,undefined

[38] and Institute for Regenerative Medicine,undefined

[39] Schools of Veterinary Medicine and Medicine,undefined

[40] University of Pennsylvania,undefined

[41] Discovery Sciences,undefined

[42] Janssen Research and Development,undefined

[43] Broad Institute,undefined

来源：

Nature Genetics | 2017年 / 49卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Michael Kharas and colleagues characterize the MSI2 protein interactome in leukemia cells and subsequently perform a functional screen identifying 24 genes required for leukemia in vivo. They focus on the RNA-binding protein SYNCRIP, showing that it regulates Hoxa9 and other transcripts involved in a myeloid leukemia stem cell program.

引用

页码：866 / 875

页数：9

共 50 条

[31] CD99 Identifies Disease Stem Cells in Acute Myeloid Leukemia and the Myelodysplastic Syndromes
Chung, Stephen S.
Pang, Wendy W.
In, Gino K.
Jan, Max
Klimek, Virginia M.
Melnick, Ari
Weissman, Irving L.
Majeti, Ravi
Park, Christopher Y.
BLOOD, 2012, 120 (21)
[32] Characterization and functional analysis of a murine model for chronic myeloid leukemia stem cells
Sozer, S
Echlin, DR
Rossi, RM
Grimes, BA
Jordan, CT
BLOOD, 2004, 104 (11) : 202B - 202B
[33] Functional characterization of microRNAs identified in human acute myeloid leukemia stem cells
Hermans, Karin G.
Lechman, Eric R.
Dick, John E.
CANCER RESEARCH, 2012, 72
[34] A morphant screen identifies an essential role for Syndecan-2 in vascular development.
Chen, E
Nielsen, C
Hermanson, S
Ekker, SC
DEVELOPMENTAL BIOLOGY, 2003, 259 (02) : 538 - 538
[35] MSI2 PLAYS A ROLE IN GLUCOCORTICOIDS RESISTANCE OF MLL-REARRANGED ALL BY REGULATING THE ENERGY METABOLISM OF LEUKEMIC CELLS
Bardini, Michela
Valsecchi, Luigia
Naso, Simone
Procopio, Simona
Mauri, Mario
Pasquale, Valentina
Fazio, Grazia
Palmi, Chiara
Piazza, Rocco
Sacco, Elena
Biondi, Andrea
Cazzaniga, Giovanni
EXPERIMENTAL HEMATOLOGY, 2022, 111 : S60 - S60
[36] A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence
Nadine H. Brückmann
Sofie N. Bennedsen
Pascal H. G. Duijf
Mikkel G. Terp
Mads Thomassen
Martin Larsen
Christina B. Pedersen
Torben Kruse
Nicolas Alcaraz
Henrik J. Ditzel
Morten F. Gjerstorff
Cell Death & Disease, 10
[37] A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence
Brueckmann, Nadine H.
Bennedsen, Sofie N.
Duijf, Pascal H. G.
Terp, Mikkel G.
Thomassen, Mads
Larsen, Martin
Pedersen, Christina B.
Kruse, Torben
Alcaraz, Nicolas
Ditzel, Henrik J.
Gjerstorff, Morten F.
CELL DEATH & DISEASE, 2019, 10 (11)
[38] Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells
Glait-Santar, Chen
Desmond, Ronan
Feng, Xingmin
Bat, Taha
Chen, Jichun
Heuston, Elisabeth
Mizukawa, Benjamin
Mulloy, James C.
Bodine, David M.
Larochelle, Andre
Dunbar, Cynthia E.
STEM CELLS, 2015, 33 (12) : 3635 - 3642
[39] Critical Role Of Interleukin Receptor Signaling In Acute Myeloid Leukemia Identified Using An RNAi Functional Screen
Agarwal, Anupriya
Meckenzie, Ryan J.
Carey, Alyssa
Davare, Monika
Eide, Christopher A.
Watanabe-Smith, Kevin
Braziel, Rita M.
Tyner, Jeffrey W.
Bagby, Grover C.
Druker, Brian J.
BLOOD, 2013, 122 (21)
[40] PHENOTYPICAL AND FUNCTIONAL ABNORMALITIES OF MESENCHYMAL STEM CELLS FROM ACUTE MYELOID LEUKEMIA PATIENTS
Domenech, J.
Charbonnier, T.
Desbourdes, L.
Iltis, A.
Javary, J.
Gauthier, A.
Gyan, E.
Herault, O.
HAEMATOLOGICA, 2012, 97 : 15 - 15

← 1 2 3 4 5 →