Heparin resistance in COVID-19 patients in the intensive care unit

被引：143

作者：

White, D. ^{[1
]}

MacDonald, S. ^{[1
]}

Bull, T. ^{[1
]}

Hayman, M. ^{[1
]}

de Monteverde-Robb, R. ^{[2
]}

Sapsford, D. ^{[2
]}

Lavinio, A. ^{[3
]}

Varley, J. ^{[3
]}

Johnston, A. ^{[3
]}

Besser, M. ^{[1
]}

Thomas, W. ^{[1
]}

机构：

[1] Cambridge Univ Hosp NHS Fdn Trust, Dept Haematol, Cambridge, England

[2] Cambridge Univ Hosp NHS Fdn Trust, Pharm Dept, Cambridge, England

[3] Cambridge Univ Hosp NHS Fdn Trust, Dept Intens Care Med, Cambridge, England

来源：

JOURNAL OF THROMBOSIS AND THROMBOLYSIS | 2020年 / 50卷 / 02期

关键词：

Thrombosis; Intensive care; COVID-19; Heparin;

D O I：

10.1007/s11239-020-02145-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with COVID-19 have a coagulopathy and high thrombotic risk. In a cohort of 69 intensive care unit (ICU) patients we investigated for evidence of heparin resistance in those that have received therapeutic anticoagulation. 15 of the patients have received therapeutic anticoagulation with either unfractionated heparin (UFH) or low molecular weight heparin (LMWH), of which full information was available on 14 patients. Heparin resistance to UFH was documented in 8/10 (80%) patients and sub-optimal peak anti-Xa following therapeutic LMWH in 5/5 (100%) patients where this was measured (some patients received both anticoagulants sequentially). Spiking plasma from 12 COVID-19 ICU patient samples demonstrated decreased in-vitro recovery of anti-Xa compared to normal pooled plasma. In conclusion, we have found evidence of heparin resistance in critically unwell COVID-19 patients. Further studies investigating this are required to determine the optimal thromboprophylaxis in COVID-19 and management of thrombotic episodes.

引用

页码：287 / 291

页数：5

共 50 条

[31] Intensive Care Unit Nurses' Experiences of Caring for COVID-19 Patients
Levi, Paula
Moss, Jacqueline
WORKPLACE HEALTH & SAFETY, 2021, 69 (10) : 486 - 487
[32] Bacterial infections in COVID-19 patients hospitalized in intensive care unit
Bravo, Felipe
Galvan, Gonzalo
Arancibia, Jose M.
REVISTA CHILENA DE INFECTOLOGIA, 2022, 39 (02): : 224 - 226
[33] Factors associated with admission of COVID-19 patients in intensive care unit
Bakebe, Alain
Cobarzan, Daniel
Chaouche, Kamel
Oliviero, Gerard
Durup, Florence
Benhamida, Sarah
Decoux, Laurent
EUROPEAN RESPIRATORY JOURNAL, 2021, 58
[34] Acute myopathic quadriplegia in patients with COVID-19 in the intensive care unit
Madia, Francesca
Merico, Barbara
Primiano, Guido
Cutuli, Salvatore Lucio
De Pascale, Gennaro
Servidei, Serenella
NEUROLOGY, 2020, 95 (11) : 492 - 494
[35] The Evaluation of COVID-19 Patients Treated with HFNC in Intensive Care Unit
Karcioglu, Ayse Muge
Atli, Hatice Zeynep
Karcioglu, Oguz
Turan, Isil Ozkocak
TURKISH JOURNAL OF INTENSIVE CARE-TURK YOGUN BAKIM DERGISI, 2022, 20 : 91 - 98
[36] Intensive Care of Patients with COVID-19
S. S. Petrikov
K. A. Popugaev
S. V. Zhuravel’
Herald of the Russian Academy of Sciences, 2022, 92 : 418 - 424
[37] Intensive Care of Patients with COVID-19
Petrikov, S. S.
Popugaev, K. A.
Zhuravel, S., V
HERALD OF THE RUSSIAN ACADEMY OF SCIENCES, 2022, 92 (04) : 418 - 424
[38] COMPARISON OF PSYCHIATRIC SYMPTOMS IN PATIENTS WITH COVID-19 HOSPITALIZED IN INTENSIVE CARE UNIT AND NON-INTENSIVE CARE UNIT
Kapici, Yasar
Tekin, Atilla
PSYCHIATRIA DANUBINA, 2022, 34 (01) : 157 - 163
[39] Post-Intensive Care Syndrome in Covid-19 Patients Discharged From the Intensive Care Unit
Gardashkhani, Sevda
Ajri-Khameslou, Mehdi
Heidarzadeh, Mehdi
Sedigh, SeyedMohammad Rajaei
JOURNAL OF HOSPICE & PALLIATIVE NURSING, 2021, 23 (06) : 530 - 538
[40] COVID-19 and the Transformation of Intensive Care Unit Telemedicine
Cucchi, Eric W.
Kopec, Scott E.
Lilly, Craig M.
CLINICS IN CHEST MEDICINE, 2022, 43 (03) : 529 - 538

← 1 2 3 4 5 →