Nanostructured magnetic systems have many applications, including potential use in cancer therapy deriving from their ability to heat in alternating magnetic fields. In this work we explore the influence of particle chain formation on the normalized heating properties, or specific loss power (SLP) of both low- (spherical) and high- (parallelepiped) anisotropy ferrite-based magnetic fluids. Analysis of ferromagnetic resonance (FMR) data shows that high particle concentrations correlate with increasing chain length producing decreasing SLP. Monte Carlo simulations corroborate the FMR results. We propose a theoretical model describing dipole interactions valid for the linear response regime to explain the observed trends. This model predicts optimum particle sizes for hyperthermia to about 30% smaller than those previously predicted, depending on the nanoparticle parameters and chain size. Also, optimum chain lengths depended on nanoparticle surface-to-surface distance. Our results might have important implications to cancer treatment and could motivate new strategies to optimize magnetic hyperthermia.
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Univ York, Dept Phys, York YO10 5DD, N Yorkshire, EnglandUniv York, Dept Phys, York YO10 5DD, N Yorkshire, England
Drayton, A.
Zehner, J.
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Univ York, Dept Phys, York YO10 5DD, N Yorkshire, EnglandUniv York, Dept Phys, York YO10 5DD, N Yorkshire, England
Zehner, J.
Timmis, J.
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Liquids Res Ltd, Unit Mentec 9, Deiniol Rd, Bangor LL57 2UP, Gwynedd, WalesUniv York, Dept Phys, York YO10 5DD, N Yorkshire, England
Timmis, J.
Patel, V.
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Liquids Res Ltd, Unit Mentec 9, Deiniol Rd, Bangor LL57 2UP, Gwynedd, WalesUniv York, Dept Phys, York YO10 5DD, N Yorkshire, England
Patel, V.
Vallejo-Fernandez, G.
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Univ York, Dept Phys, York YO10 5DD, N Yorkshire, EnglandUniv York, Dept Phys, York YO10 5DD, N Yorkshire, England
Vallejo-Fernandez, G.
O'Grady, K.
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Univ York, Dept Phys, York YO10 5DD, N Yorkshire, England
Liquids Res Ltd, Unit Mentec 9, Deiniol Rd, Bangor LL57 2UP, Gwynedd, WalesUniv York, Dept Phys, York YO10 5DD, N Yorkshire, England
机构:
Tohoku Univ, Grad Sch Engn, Sendai, Miyagi 9800865, JapanTohoku Univ, Grad Sch Engn, Sendai, Miyagi 9800865, Japan
Adachi, Yuui
Kuwahata, Akihiro
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Tohoku Univ, Grad Sch Engn, Sendai, Miyagi 9800865, JapanTohoku Univ, Grad Sch Engn, Sendai, Miyagi 9800865, Japan
Kuwahata, Akihiro
Nakamura, Eiji
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Tohoku Univ, Grad Sch Engn, Sendai, Miyagi 9800865, Japan
High Energy Accelerator Res Org KEK, Tsukuba 3050801, JapanTohoku Univ, Grad Sch Engn, Sendai, Miyagi 9800865, Japan
Nakamura, Eiji
Yabukami, Shin
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Tohoku Univ, Grad Sch Engn, Sendai, Miyagi 9800865, Japan
Tohoku Univ, Dept Biomed Engn, Sendai, Miyagi 9808579, JapanTohoku Univ, Grad Sch Engn, Sendai, Miyagi 9800865, Japan
机构:
CSIC, ICMM, C Sor Juana Ines de la Cruz 6, Madrid 28049, Spain
Inst Magnetismo Aplicado RENFE UCM CSIC, POB 155, Las Rozas 28230, SpainCSIC, ICMM, C Sor Juana Ines de la Cruz 6, Madrid 28049, Spain
Ovejero, J. G.
Cabrera, D.
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IMdea Nanociencia, Campus Univ Cantoblanco, Madrid 28049, SpainCSIC, ICMM, C Sor Juana Ines de la Cruz 6, Madrid 28049, Spain
Cabrera, D.
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Carrey, J.
Valdivielso, T.
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IMdea Nanociencia, Campus Univ Cantoblanco, Madrid 28049, SpainCSIC, ICMM, C Sor Juana Ines de la Cruz 6, Madrid 28049, Spain
Valdivielso, T.
Salas, G.
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CSIC, ICMM, C Sor Juana Ines de la Cruz 6, Madrid 28049, Spain
IMdea Nanociencia, Campus Univ Cantoblanco, Madrid 28049, Spain
Unidad Asociada Ctr Nacl Biotecnol CSIC, Nanobiotecnol IMdea Nanociencia, Madrid 28049, SpainCSIC, ICMM, C Sor Juana Ines de la Cruz 6, Madrid 28049, Spain
Salas, G.
Teran, F. J.
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IMdea Nanociencia, Campus Univ Cantoblanco, Madrid 28049, Spain
Unidad Asociada Ctr Nacl Biotecnol CSIC, Nanobiotecnol IMdea Nanociencia, Madrid 28049, SpainCSIC, ICMM, C Sor Juana Ines de la Cruz 6, Madrid 28049, Spain