The role of the alternative respiratory pathway in the stimulation of cephalosporin C formation by soybean oil in Acremonium chrysogenum

被引：0
|
作者：
L. Karaffa
E. Sándor
J. Kozma
C. P. Kubicek
A. Szentirmai
机构：
[1] Department of Microbiology and Biotechnology,
[2] Kossuth Lajos University,undefined
[3] H-4010,undefined
[4] Debrecen,undefined
[5] P.O.Box 63,undefined
[6] Hungary e-mail: KARAFFAL@TIGRIS.KLTE.HU Tel.: +36-52-316-666 ext. 2488 Fax: +36-52-310-936,undefined
[7] Steroid Bioconversion Laboratory,undefined
[8] Chemical Works of Richter Gedeon Ltd.,undefined
[9] H-1103,undefined
[10] Gyömrõi út 19-21,undefined
[11] Budapest,undefined
[12] Hungary,undefined
[13] Section Microbial Biochemistry,undefined
[14] Institute of Biochemical Technology and Microbiology,undefined
[15] TU Vienna,undefined
[16] Getreidemarkt 9/172.5,undefined
[17] A-1060,undefined
[18] Vienna,undefined
[19] Austria,undefined
来源：
Applied Microbiology and Biotechnology | 1999年 / 51卷
关键词：
Sugar; Respiration; Respiratory Pathway; Succinate; Cephalosporin;
D O I：
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中图分类号：
学科分类号：
摘要：
Addition of soybean oil to Acremonium chrysogenum cultures growing on sugars doubled the specific production of cephalosporin C during the idiophase of growth. While the addition of soybean oil had no effect on the total rate of respiration, the respiration that proceeded via the alternative, cyanide-insensitive pathway exhibited a more than twofold increase. Addition of soybean oil also stimulated the formation of isocitrate lyase activities. Inhibition of oxidative metabolism of one of the products of isocitrate lyase (succinate) by thenoyltrifluoroacetone completely inhibited the alternative respiratory pathway. The role of soybean-oil-stimulated alternative respiration in the stimulation of cephalosporin C production and the role of isocitrate lyase are discussed.
引用
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页码：633 / 638
页数：5
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