Suppression of PI3K/Akt/mTOR Signaling Pathway and Antioxidant System and Reversal of Cancer Cells Resistance to Cisplatin under the Effect of Curcumin

被引：0
|
作者：
E. V. Kalinina
A. A. Sh. Hasan
V. V. Tatarskiy
Yu. L. Volodina
А. S. Petrova
M. D. Novichkova
D. D. Zhdanov
N. K. Nurmuradov
N. N. Chernov
A. A. Shtil
机构：
[1] Peoples’ Friendship University of Russia (RUDN University),T. T. Berezov Department of Biochemistry
[2] Ministry of Health of the Russian Federation,Laboratory of Tumor Cell Death, N. N. Blokhin National Medical Research Center of Oncology
来源：
Bulletin of Experimental Biology and Medicine | 2022年 / 173卷
关键词：
tumor cells drug resistance; gene expression; PI3K/AkT/mTOR signaling pathway; cisplatin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effect of curcumin on the resistance of SKOV-3 human ovarian adenocarcinoma cells to cisplatin was studied. It was found that curcumin induced “reversal” of cancer cells resistance, which was associated with suppression of the expression of genes encoding the key antioxidant enzymes (SOD1, SOD2, CAT, GPX1, and HO-1) and transcription factor Nrf2 and a decrease in the expression of genes encoding kinases of the PI3K/Akt/mTOR signaling pathway. The obtained results confirm the role of redox-dependent regulation in the “reversal” of cancer cells resistance to cisplatin.
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页码：371 / 375
页数：4
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