Suppression of PI3K/Akt/mTOR Signaling Pathway and Antioxidant System and Reversal of Cancer Cells Resistance to Cisplatin under the Effect of Curcumin

被引：0

作者：

E. V. Kalinina

A. A. Sh. Hasan

V. V. Tatarskiy

Yu. L. Volodina

А. S. Petrova

M. D. Novichkova

D. D. Zhdanov

N. K. Nurmuradov

N. N. Chernov

A. A. Shtil

机构：

[1] Peoples’ Friendship University of Russia (RUDN University),T. T. Berezov Department of Biochemistry

[2] Ministry of Health of the Russian Federation,Laboratory of Tumor Cell Death, N. N. Blokhin National Medical Research Center of Oncology

来源：

Bulletin of Experimental Biology and Medicine | 2022年 / 173卷

关键词：

tumor cells drug resistance; gene expression; PI3K/AkT/mTOR signaling pathway; cisplatin;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The effect of curcumin on the resistance of SKOV-3 human ovarian adenocarcinoma cells to cisplatin was studied. It was found that curcumin induced “reversal” of cancer cells resistance, which was associated with suppression of the expression of genes encoding the key antioxidant enzymes (SOD1, SOD2, CAT, GPX1, and HO-1) and transcription factor Nrf2 and a decrease in the expression of genes encoding kinases of the PI3K/Akt/mTOR signaling pathway. The obtained results confirm the role of redox-dependent regulation in the “reversal” of cancer cells resistance to cisplatin.

引用

页码：371 / 375

页数：4

共 50 条

[1] Suppression of PI3K/Akt/mTOR Signaling Pathway and Antioxidant System and Reversal of Cancer Cells Resistance to Cisplatin under the Effect of Curcumin
Kalinina, E., V
Hasan, A. A. Sh
Tatarskiy, V. V.
Volodina, Yu L.
Petrova, A. S.
Novichkova, M. D.
Zhdanov, D. D.
Nurmuradov, K.
Chernov, N. N.
Shtil, A. A.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2022, 173 (03) : 371 - 375
[2] Suppression of the Antioxidant System and PI3K/Akt/mTOR Signaling Pathway in Cisplatin-Resistant Cancer Cells by Quercetin
A. A. Sh. Hasan
E. V. Kalinina
V. V. Tatarskiy
Yu. L. Volodina
А. S. Petrova
M. D. Novichkova
D. D. Zhdanov
A. A. Shtil
Bulletin of Experimental Biology and Medicine, 2022, 173 : 760 - 764
[3] Suppression of the Antioxidant System and PI3K/Akt/mTOR Signaling Pathway in Cisplatin-Resistant Cancer Cells by Quercetin
Hasan, A. A. Sh
Kalinina, E., V
Tatarskiy, V. V.
Volodina, Yu L.
Petrova, A. S.
Novichkova, M. D.
Zhdanov, D. D.
Shtil, A. A.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2022, 173 (06) : 760 - 764
[4] PI3K/Akt/mTOR signaling pathway in cancer stem cells
Fath, Mohsen Karami
Ebrahimi, Menooa
Nourbakhsh, Ehsan
Hazara, Ahmad Zia
Mirzaei, Ali
Shafieyari, Saba
Salehi, Azadeh
Hoseinzadeh, Mahsa
Payandeh, Zahra
Barati, Ghasem
PATHOLOGY RESEARCH AND PRACTICE, 2022, 237
[5] Effect of Curcumin on Gene Expression of Trx/TxrR System and PI3K/Akt/mTOR Signaling Pathway in SKOV3 Cells Resistant to Cisplatin
Kalinina, Elena
Hasan, Aseel Ali
Petrova, Albina
Novichkova, Maria
Zhdanov, Dmitry
Shtil, Alexander
Chernov, Nikolai
FREE RADICAL BIOLOGY AND MEDICINE, 2020, 159 : S55 - S55
[6] The PI3K/Akt/mTOR signaling pathway
Dennis, P. A.
ANNALS OF ONCOLOGY, 2011, 22 : 19 - 19
[7] Reversal of cisplatin resistance by inhibiting PI3K/Akt signal pathway in human lung cancer cells
Zhang, Y.
Bao, C.
Mu, Q.
Chen, J.
Wang, J.
Mi, Y.
Sayari, A. J.
Chen, Y.
Guo, M.
NEOPLASMA, 2016, 63 (03) : 362 - 370
[8] The PI3K/AKT/MTOR signaling pathway: The role of PI3K and AKT inhibitors in breast cancer
Huemer F.
Bartsch R.
Gnant M.
Current Breast Cancer Reports, 2014, 6 (2) : 59 - 70
[9] Resistance to Cisplatin in NSCLC is Related to Autophagy Induced by PI3K/AKT/mTOR Signaling Pathway Inhibition
Peng, Ling
Miao, Ya-Fang
Chen, Hao
Wang, Qiu-Bo
Wang, An
Xue, Fei
Zhou, Chao
LATIN AMERICAN JOURNAL OF PHARMACY, 2020, 39 (03): : 482 - 489
[10] Inhibition of esophageal cancer growth through the suppression of PI3K/AKT/mTOR signaling pathway
Shi, Ni
Yu, Hao
Chen, Tong
ONCOTARGETS AND THERAPY, 2019, 12 : 7637 - 7647

← 1 2 3 4 5 →