Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E

被引：0

作者：

Y. Inoshima

T. Miyazawa

M. Kohmoto

Y. Ikeda

E. Sato

T. Hohdatsu

C. Mathiason-Dubard

E. A. Hoover

T. Mikami

机构：

[1] Department of Veterinary Microbiology,

[2] Graduate School of Agricultural and Life Sciences,undefined

[3] The University of Tokyo,undefined

[4] Tokyo,undefined

[5] Japan,undefined

[6] Department of Veterinary Infectious Diseases,undefined

[7] School of Veterinary Medicine and Animal Sciences,undefined

[8] Kitasato University,undefined

[9] Aomori,undefined

[10] Japan,undefined

[11] Department of Pathology,undefined

[12] Colorado State University,undefined

[13] Fort Collins,undefined

[14] Colorado,undefined

[15] U.S.A.,undefined

来源：

Archives of Virology | 1998年 / 143卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.

引用

页码：157 / 162

页数：5

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