Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E

被引:0
|
作者
Y. Inoshima
T. Miyazawa
M. Kohmoto
Y. Ikeda
E. Sato
T. Hohdatsu
C. Mathiason-Dubard
E. A. Hoover
T. Mikami
机构
[1] Department of Veterinary Microbiology,
[2] Graduate School of Agricultural and Life Sciences,undefined
[3] The University of Tokyo,undefined
[4] Tokyo,undefined
[5] Japan,undefined
[6] Department of Veterinary Infectious Diseases,undefined
[7] School of Veterinary Medicine and Animal Sciences,undefined
[8] Kitasato University,undefined
[9] Aomori,undefined
[10] Japan,undefined
[11] Department of Pathology,undefined
[12] Colorado State University,undefined
[13] Fort Collins,undefined
[14] Colorado,undefined
[15] U.S.A.,undefined
来源
Archives of Virology | 1998年 / 143卷
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学科分类号
摘要
Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.
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页码:157 / 162
页数:5
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