Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

被引：0
|
作者：
Lucia Ricci-Vitiani
Roberto Pallini
Mauro Biffoni
Matilde Todaro
Gloria Invernici
Tonia Cenci
Giulio Maira
Eugenio Agostino Parati
Giorgio Stassi
Luigi Maria Larocca
Ruggero De Maria
机构：
[1] Oncology and Molecular Medicine,Department of Hematology
[2] Istituto Superiore di Sanità,Department of Neurosurgery
[3] Viale Regina Elena 299,Department of Surgical and Oncological Sciences
[4] Catholic University of Rome,undefined
[5] Largo Francesco Vito 1,undefined
[6] University of Palermo,undefined
[7] Via Liborio Giuffrè 5,undefined
[8] U. O. Cerebrovascular Disease Cellular Neurobiology Laboratory,undefined
[9] Fondazione IRCCS,undefined
[10] Neurological Institute “Carlo Besta”,undefined
[11] Via Celoria 11,undefined
[12] Institute of Pathology,undefined
[13] Catholic University of Rome,undefined
[14] Largo Francesco Vito 1,undefined
[15] Cellular and Molecular Oncology,undefined
[16] Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Salvatore Maugeri,undefined
[17] Via S. Maugeri 6,undefined
[18] Mediterranean Institute of Oncology,undefined
[19] Via Penninazzo 7,undefined
[20] 95029,undefined
[21] Viagrande,undefined
[22] Catania,undefined
[23] Italy ,undefined
来源：
Nature | 2010年 / 468卷
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摘要：
Glioblastomas are aggressive brain cancers that are nourished by an extensive network of blood vessels. Two groups now show that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells and seem to be derived from glioblastoma stem-like cells. This work suggests that some putative cancer stem cells promote cancer growth both directly and indirectly, and may explain the failure of certain anti-angiogenic cancer drugs and aid the design of new therapies.
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页码：824 / 828
页数：4
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