The epigenetics of epithelial-mesenchymal plasticity in cancer

被引：0
|
作者：
Wai Leong Tam
Robert A Weinberg
机构：
[1] Whitehead Institute for Biomedical Research,Department of Biology
[2] Ludwig Center for Molecular Oncology,undefined
[3] Massachusetts Institute of Technology (MIT),undefined
[4] MIT,undefined
来源：
Nature Medicine | 2013年 / 19卷
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学科分类号：
摘要：
Epithelial-mesenchymal transitions (EMTs) are a key requirement for cancer cells to metastasize and colonize in a new environment. Epithelial-mesenchymal plasticity is mediated by master transcription factors and is also subject to complex epigenetic regulation. This Review outlines our current understanding of the interactions between EMT-inducing transcription factors and epigenetic modulators during cancer progression and the therapeutic implications of exploiting this intricate regulatory process.
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页码：1438 / 1449
页数：11
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