Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside

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作者
Jill P Buyon
Robert M Clancy
Deborah M Friedman
机构
[1] New York Medical College,JP Buyon is Professor and Associate Director of the Division of Rheumatology
[2] New York,undefined
[3] NY,undefined
[4] USA.,undefined
[5] RM Clancy is Associate Professor at the New York University School of Medicine,undefined
[6] New York,undefined
[7] NY,undefined
[8] USA.,undefined
[9] DM Friedman is Professor of Pediatric Cardiology at the New York Medical College,undefined
[10] New York,undefined
[11] NY,undefined
[12] USA.,undefined
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摘要
Congenital heart block is a serious cardiac manifestation of neonatal lupus erythematosus that is associated with exposure to maternal autoantibodies against components of the SSA/Ro–SSB/La ribonucleoprotein complex. This Review outlines our current hypothesis regarding the pathogenesis of this disease and discusses how basic research can be applied to ensure appropriate prevention and management strategies are followed.
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页码:139 / 148
页数:9
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