An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

被引:0
|
作者
Karen I Zeller
Anil G Jegga
Bruce J Aronow
Kathryn A O'Donnell
Chi V Dang
机构
[1] The Sidney Kimmel Comprehensive Cancer Center,Division of Hematology, Department of Medicine
[2] The Johns Hopkins University School of Medicine,Divisions of Pediatric Informatics and Molecular Developmental Biology
[3] Children's Hospital Research Foundation,Program in Human Genetics and Molecular Biology
[4] Children's Hospital Medical Center and Department of Biomedical Engineering,undefined
[5] University of Cincinnati,undefined
[6] The Johns Hopkins University School of Medicine,undefined
来源
Genome Biology | / 4卷
关键词
Chromatin Immunoprecipitation; Putative Target Gene; Phylogenetic Footprinting; Direct Target Gene; DDX18 Gene;
D O I
暂无
中图分类号
学科分类号
摘要
We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.
引用
收藏
相关论文
共 50 条
  • [41] Identification of Druggable Genes for Asthma by Integrated Genomic Network Analysis
    Adikusuma, Wirawan
    Chou, Wan-Hsuan
    Lin, Min-Rou
    Ting, Jafit
    Irham, Lalu Muhammad
    Perwitasari, Dyah Aryani
    Chang, Wei-Pin
    Chang, Wei-Chiao
    BIOMEDICINES, 2022, 10 (01)
  • [42] IDENTIFICATION AND FUNCTIONAL STUDY OF DIRECT REGULATORY TARGETS OF THE HMG-BOX TRANSCRIPTION FACTOR SOX2
    Lee, K. E.
    Ji, E. H.
    Seong, I. J.
    Jeong, H. Y.
    Choi, M. K.
    Kim, J. S.
    JOURNAL OF NEUROCHEMISTRY, 2009, 110 : 229 - 229
  • [43] Genetic lesions in MYC and STAT3 drive oncogenic transcription factor overexpression in plasmablastic lymphoma
    Garcia-Reyero, Julia
    Martinez Magunacelaya, Nerea
    Gonzalez de Villambrosia, Sonia
    Loghavi, Sanam
    Gomez Mediavilla, Angela
    Tonda, Raul
    Beltran, Sergi
    Gut, Marta
    Perena Gonzalez, Ainara
    D'Amore, Emmanuel
    Visco, Carlo
    Khoury, Joseph D.
    Montes-Moreno, Santiago
    HAEMATOLOGICA, 2021, 106 (04) : 1120 - 1128
  • [44] Multiple transcription-factor genes are early targets of phytochrome A signaling
    Tepperman, JM
    Zhu, T
    Chang, HS
    Wang, X
    Quail, PH
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (16) : 9437 - 9442
  • [45] wDBTF: an integrated database resource for studying wheat transcription factor families
    Romeuf, Isabelle
    Tessier, Dominique
    Dardevet, Mireille
    Branlard, Gerard
    Charmet, Gilles
    Ravel, Catherine
    BMC GENOMICS, 2010, 11
  • [46] wDBTF: an integrated database resource for studying wheat transcription factor families
    Isabelle Romeuf
    Dominique Tessier
    Mireille Dardevet
    Gérard Branlard
    Gilles Charmet
    Catherine Ravel
    BMC Genomics, 11
  • [47] A microarray screen for direct targets of the Zic1 transcription factor
    Hassan, Sabah M.
    Li, Shuzhao
    Merzdorf, Christa
    DEVELOPMENTAL BIOLOGY, 2007, 306 (01) : 356 - 356
  • [48] The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes
    Pizzolato, Giulia
    Moparthi, Lavanya
    Soderholm, Simon
    Cantu, Claudio
    Koch, Stefan
    JOURNAL OF CELL SCIENCE, 2022, 135 (19)
  • [49] Genome-wide analysis and identification of abiotic stress responsive transcription factor family genes and miRNAs in bread wheat (Triticumaestivum L.) Genomic study of bread wheat
    Sahu, Sarika
    Rao, A. R.
    Bansal, K. C.
    Muthusamy, S. K.
    Chinnusamy, V.
    2016 INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND SYSTEMS BIOLOGY (BSB), 2016,
  • [50] Genomic identification and characterization of MYC family genes in wheat (Triticum aestivum L.)
    Bai, Jian-fang
    Wang, Yu-kun
    Guo, Li-ping
    Guo, Xiao-ming
    Guo, Hao-yu
    Yuan, Shao-hua
    Duan, Wen-jing
    Liu, Zihan
    Zhao, Chang-ping
    Zhang, Feng-ting
    Zhang, Li-ping
    BMC GENOMICS, 2019, 20 (01)