Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography

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作者
Jun Song
Christine Leon Swisher
Hyungsoon Im
Sangmoo Jeong
Divya Pathania
Yoshiko Iwamoto
Misha Pivovarov
Ralph Weissleder
Hakho Lee
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[1] Center for Systems Biology,Department of Radiology
[2] Massachusetts General Hospital,Department of Systems Biology
[3] School of Engineering and Applied Sciences,undefined
[4] Harvard University,undefined
[5] Massachusetts General Hospital,undefined
[6] Harvard Medical School,undefined
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Lens-free digital in-line holography (LDIH) is a promising technology for portable, wide field-of-view imaging. Its resolution, however, is limited by the inherent pixel size of an imaging device. Here we present a new computational approach to achieve sub-pixel resolution for LDIH. The developed method is a sparsity-based reconstruction with the capability to handle the non-linear nature of LDIH. We systematically characterized the algorithm through simulation and LDIH imaging studies. The method achieved the spatial resolution down to one-third of the pixel size, while requiring only single-frame imaging without any hardware modifications. This new approach can be used as a general framework to enhance the resolution in nonlinear holographic systems.
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