Modification of recombinant proteins by covalent polysialation illustrated with the example of human insulin

被引：0

作者：

V. V. Bezuglov

N. M. Greskaya

M. Yu. Bobrov

M. G. Akimov

E. V. Fomina-Ageeva

G. N. Zinchenko

D. I. Bairamashvili

A. I. Miroshnikov

机构：

[1] Russian Academy of Sciences,Shemyakin

来源：

Russian Journal of Bioorganic Chemistry | 2009年 / 35卷

关键词：

recombinant human insulin; polysialic acid;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Methods of selective and nonselective covalent immobilization of genetically engineered proteins on molecules of natural polysialic acid are described by the example of human insulin. Such modification increases insulin lifetime in vivo.

引用

页码：254 / 257

页数：3

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