New frontiers in immune checkpoint B7-H3 (CD276) research and drug development

被引：0
|
作者：
Ayechew Adera Getu
Abiye Tigabu
Ming Zhou
Jianrong Lu
Øystein Fodstad
Ming Tan
机构：
[1] Institute of Biochemistry and Molecular Biology,Department of Physiology, School of Medicine, College of Medicine and Health Sciences
[2] Institute of Biomedical Sciences,Department of Biochemistry and Molecular Biology, College of Medicine
[3] and Research Center for Cancer Biology,undefined
[4] China Medical University,undefined
[5] University of Gondar,undefined
[6] Cancer Research Institute and School of Basic Medical Sciences,undefined
[7] Central South University,undefined
[8] University of Florida,undefined
[9] Department of Tumor Biology,undefined
[10] Institute for Cancer Research,undefined
[11] Oslo University Hospital Radiumhospitalet,undefined
来源：
Molecular Cancer | / 22卷
关键词：
B7-H3; CD276; Cancer; Immunotherapy; Drug Development;
D O I：
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学科分类号：
摘要：
B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer progression. This immune checkpoint molecule is selectively expressed in both tumor cells and immune cells within the tumor microenvironment. In addition to its immune checkpoint function, B7-H3 has been linked to tumor cell proliferation, metastasis, and therapeutic resistance. Furthermore, its drastic difference in protein expression levels between normal and tumor tissues suggests that targeting B7-H3 with drugs would lead to cancer-specific toxicity, minimizing harm to healthy cells. These properties make B7-H3 a promising target for cancer therapy.
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