Genome-wide association studies in pediatric chronic kidney disease

被引：0

作者：

Jayanta Gupta

Peter A. Kanetsky

Matthias Wuttke

Anna Köttgen

Franz Schaefer

Craig S. Wong

机构：

[1] Texas Tech University Health Sciences Center,Department of Biomedical Sciences

[2] H. Lee Moffitt Cancer Center and Research Institute,Department of Cancer Epidemiology

[3] Medical Center - University of Freiburg,Renal Division

[4] University of Heidelberg,Pediatric Nephrology Division

[5] University of New Mexico Children’s Hospital,Department of Pediatrics, Division of Nephrology

来源：

Pediatric Nephrology | 2016年 / 31卷

关键词：

Genome-wide association study (GWAS); Chronic kidney disease; Translational medicine; Pediatric; Genetics;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The genome-wide association study (GWAS) has become an established scientific method that provides an unbiased screen for genetic loci potentially associated with phenotypes of clinical interest, such as chronic kidney disease (CKD). Thus, GWAS provides opportunities to gain new perspectives regarding the genetic architecture of CKD progression by identifying new candidate genes and targets for intervention. As such, it has become an important arm of translational science providing a complementary line of investigation to identify novel therapeutics to treat CKD. In this review, we describe the method and the challenges of performing GWAS in the pediatric CKD population. We also provide an overview of successful GWAS for kidney disease, and we discuss the established pediatric CKD cohorts in North America and Europe that are poised to identify genetic risk variants associated with CKD progression.

引用

页码：1241 / 1252

页数：11

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