Aberrant stability of brain functional architecture in cirrhotic patients with minimal hepatic encephalopathy

被引:0
|
作者
Li-Min Cai
Jia-Yan Shi
Qiu-Yi Dong
Jin Wei
Hua-Jun Chen
机构
[1] Fujian Medical University Union Hospital,Department of Radiology
来源
Brain Imaging and Behavior | 2022年 / 16卷
关键词
Functional stability; Dynamic functional connectivity; Functional magnetic resonance imaging; Resting state; Minimal hepatic encephalopathy;
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学科分类号
摘要
To investigate the stability changes of brain functional architecture and the relationship between stability change and cognitive impairment in cirrhotic patients. Fifty-one cirrhotic patients (21 with minimal hepatic encephalopathy (MHE) and 30 without MHE (NHE)) and 29 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging and neurocognitive assessment using the Psychometric Hepatic Encephalopathy Score (PHES). Voxel-wise functional connectivity density (FCD) was calculated as the sum of connectivity strength between one voxel and others within the entire brain. The sliding window correlation approach was subsequently utilized to calculate the FCD dynamics over time. Functional stability (FS) is measured as the concordance of dynamic FCD. From HCs to the NHE and MHE groups, a stepwise reduction of FS was found in the right supramarginal gyrus (RSMG), right middle cingulate cortex, left superior frontal gyrus, and bilateral posterior cingulate cortex (BPCC), whereas a progressive increment of FS was observed in the left middle occipital gyrus (LMOG) and right temporal pole (RTP). The mean FS values in RSMG/LMOG/RTP (r = 0.470 and P = 0.001; r = −0.458 and P = 0.001; and r = −0.384 and P = 0.005, respectively) showed a correlation with PHES in cirrhotic patients. The FS index in RSMG/LMOG/BPCC/RTP showed moderate discrimination potential between the NHE and MHE groups. Changes in FS may be linked to neuropathological bias of cognitive impairment in cirrhotic patients and could serve as potential biomarkers for MHE diagnosis and monitoring the progression of hepatic encephalopathy.
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页码:2258 / 2267
页数:9
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