Molecular docking analysis reveals the functional inhibitory effect of Genistein and Quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein

被引：0
|
作者：
Reji Manjunathan
Vijayalakshmi Periyaswami
Kartik Mitra
Arokiaraj Sherlin Rosita
Medha Pandya
Jayaraman Selvaraj
Lokesh Ravi
Nalini Devarajan
Mukesh Doble
机构：
[1] University of Madras,Department of Genetics, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus
[2] Chengalpattu Government Medical College and Hospital,Multi
[3] Bharathidasan University,Disciplinary Research Unit
[4] Indian Institute of Technology Madras,Department of Biotechnology and Bioinformatics, Holy Cross College
[5] Bishop Heber College (Autonomous,Bioengineering and Drug Design Lab, Department of Biotechnology
[6] Bharathidasan University),Department of Bioinformatics
[7] Maharaja KrishnakumarSinhiji Bhavnagar University,KPES Science College
[8] Saveetha Institute of Medical and Technical Sciences,Saveetha Dental College and Hospitals
[9] St. Josephs College,Department of Botany
[10] Meenakshi Ammal Dental College,Central Research Laboratory
[11] Saveetha Dental College and Hospital,Department of Cariology
来源：
BMC Bioinformatics | / 23卷
关键词：
Transmembrane serine protease 2; SARS-Cov-2 coronavirus; Phyto compounds; Bioinformatics tools; Molecular docking; Molecular dynamics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Molecular docking analysis reveals the functional inhibitory effect of Genistein and Quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein
    Manjunathan, Reji
    Periyaswami, Vijayalakshmi
    Mitra, Kartik
    Rosita, Arokiaraj Sherlin
    Pandya, Medha
    Selvaraj, Jayaraman
    Ravi, Lokesh
    Devarajan, Nalini
    Doble, Mukesh
    BMC BIOINFORMATICS, 2022, 23 (01)
  • [2] Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat
    Hempel, Tim
    Raich, Lluis
    Olsson, Simon
    Azouz, Nurit P.
    Klingler, Andrea M.
    Hoffmann, Markus
    Pohlmann, Stefan
    Rothenberg, Marc E.
    Noe, Frank
    CHEMICAL SCIENCE, 2021, 12 (03) : 983 - 992
  • [3] Molecular docking between human TMPRSS2 and SARS-CoV-2 spike protein: conformation and intermolecular interactions
    Hussain, Mushtaq
    Jabeen, Nusrat
    Amanullah, Anusha
    Baig, Ayesha Ashraf
    Aziz, Basma
    Shabbir, Sanya
    Raza, Fozia
    Uddin, Nasir
    AIMS MICROBIOLOGY, 2020, 6 (03): : 350 - 360
  • [4] TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS
    Cicka, Danielle
    Niu, Qiankun
    Qui, Min
    Qian, Kun
    Miller, Eric
    Fan, Dacheng
    Mo, Xiulei
    Ivanov, Andrey A.
    Sarafianos, Stefan G.
    Du, Yuhong
    Fu, Haian
    JOURNAL OF MOLECULAR CELL BIOLOGY, 2023, 15 (03)
  • [5] Improving the Inhibition of TMPRSS2 by Molecular Docking, to Decrease the Process Infection of SARS-CoV-2
    Luis Vique-Sanchez, Jose
    BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2022, 12 (04): : 4780 - 4846
  • [6] NSP16 promotes the expression of TMPRSS2 to enhance SARS-CoV-2 cell entry
    Han, Tianyu
    Lei, Jiapeng
    Liu, Yang
    Wang, Yanan
    Xun, Wenze
    Hu, Qifan
    Peng, Qi
    Zhang, Wei
    GENES & DISEASES, 2023, 10 (03) : 723 - 726
  • [7] Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2
    Ou, Tianling
    Mou, Huihui
    Zhang, Lizhou
    Ojha, Amrita
    Choe, Hyeryun
    Farzan, Michael
    PLOS PATHOGENS, 2021, 17 (01)
  • [8] Tmprss2 specific miRNAs as promising regulators for SARS-CoV-2 entry checkpoint
    Kaur, Taruneet
    Kapila, Suman
    Kapila, Rajeev
    Kumar, Sandeep
    Upadhyay, Divya
    Kaur, Manjeet
    Sharma, Chandresh
    VIRUS RESEARCH, 2021, 294
  • [9] Improving Soluble Expression of SARS-CoV-2 Spike Priming Protease TMPRSS2 with an Artificial Fusing Protein
    Ye, Xiao
    Ling, Xue
    Wu, Min
    Bai, Guijie
    Yuan, Meng
    Rao, Lang
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (13)
  • [10] Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein
    Sagar, Satish
    Rathinavel, Ashok Kumar
    Lutz, William E.
    Struble, Lucas R.
    Khurana, Surender
    Schnaubelt, Andy T.
    Mishra, Nitish Kumar
    Guda, Chittibabu
    Palermo, Nicholas Y.
    Broadhurst, Mara J.
    Hoffmann, Tobias
    Bayles, Kenneth W.
    Reid, St. Patrick M.
    Borgstahl, Gloria E. O.
    Radhakrishnan, Prakash
    CLINICAL AND TRANSLATIONAL MEDICINE, 2021, 11 (02):
12345