Optimization and Validation of an LC Method for the Determination of Cefdinir in Dosage Form and Human Urine

被引：0

作者：

Ghada M. Hadad

Samy Emara

Waleed M. M. Mahmoud

机构：

[1] Suez Canal University,Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy

[2] Misr International University,Pharmaceutical Chemistry Department, Faculty of Pharmacy

来源：

Chromatographia | 2009年 / 70卷

关键词：

Column liquid chromatography; Urinary excretion pattern; Cefdinir;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A simple and reliable liquid chromatographic method has been developed and validated for the determination of cefdinir in human urine and capsule samples. A chromatographic separation was achieved on a C18 column using a mobile phase consisting of potassium dihydrogen phosphate (10 mM, pH 4.5)–acetonitrile (90:10, v/v). Quantitation was achieved with UV detection at 285 nm, based on peak area with linear calibration curve at a concentration range of 0.7–39 µg mL−1. This method was successfully applied for the establishment of an urinary excretion pattern after oral dose.

引用

页码：1593 / 1598

页数：5

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