Effect of a new antitumor drug cycloplatam on DNA structure and production

被引：0
|
作者：
A. G. Tikhomirov
I. S. Sokolova
L. Yu. Dederer
L. B. Gorbacheva
机构：
[1] Russian Academy of Sciences,Institute of Biochemical Physics
来源：
Bulletin of Experimental Biology and Medicine | 1998年 / 125卷
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摘要：
The new antitumor drug cycloplatam [amine (cyclopentylamine)-S-(-)-malatoplatinum(II)] caused dose-dependent formation of interstrand DNA ligationsin vitro depending on the duration of incubation. Like cisplatin, cycloplatam caused a deep and long inhibition of DNA production in tumor cells. The effect of cycloplatam in bone marrow and small intestine epithelium cells was weaker and shorter than that of cisplatin.
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页码：172 / 174
页数：2
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