Deciphering agr quorum sensing in Staphylococcus aureus: insights and therapeutic prospects

被引:9
|
作者
Vinodhini, V. [1 ]
Kavitha, M. [1 ]
机构
[1] Vellore Inst Technol, Sch Bio Sci & Technol, Vellore 632014, Tamil Nadu, India
关键词
Agr quorum sensing; AIP signal molecule; Quorum sensing; Quorum sensing inhibition; Staphylococcus aureus; ACYLHOMOSERINE LACTONE-ACYLASE; PHENOL-SOLUBLE MODULINS; HOMOSERINE LACTONE; IDENTIFICATION; RNAIII; SYSTEM; VIRULENCE; PEPTIDE; PATHOGENESIS; INHIBITOR;
D O I
10.1007/s11033-023-08930-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The emergence of superbugs like methicillin-resistant Staphylococcus aureus exposed the limitations of treating microbial infections using antibiotics. At present, the discovery of novel and convincing therapeutic methods are being executed increasingly as possible substitutes to conventional antibiotic therapies. The quorum sensing helps Staphylococcus aureus become more viable through their signaling mechanisms. In recent years, targeting the prominent factors of quorum sensing has obtained remarkable attention as a futuristic approach to dealing with bacterial pathogenicity. The standard antibiotic therapy intends to inhibit the organism by targeting specific molecules and afford a chance for the evolution of antibiotic resistance. This prompts the development of novel therapeutic strategies like inhibiting quorum sensing that can limit bacterial virulence by decreasing the selective pressure, thereby restricting antibiotic resistance evolution. This review furnishes new insights into the accessory gene regulator quorum sensing in Staphylococcus aureus and its inhibition by targeting the genes that regulate the operon. Further, this review comprehensively explores the inhibitors reported up to date and their specific targets and discusses their potentially ineffective alternative therapy against methicillin-resistant Staphylococcus aureus.
引用
收藏
页数:16
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