Drug Transfer and Metabolism by the Human Placenta

被引：0
|
作者：
Michael R. Syme
James W. Paxton
Jeffrey A. Keelan
机构：
[1] University of Auckland,Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences
来源：
Clinical Pharmacokinetics | 2004年 / 43卷
关键词：
Digoxin; Buprenorphine; Saquinavir; Human Placenta; Maternal Blood;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The major function of the placenta is to transfer nutrients and oxygen from the mother to the foetus and to assist in the removal of waste products from the foetus to the mother. In addition, it plays an important role in the synthesis of hormones, peptides and steroids that are vital for a successful pregnancy. The placenta provides a link between the circulations of two distinct individuals but also acts as a barrier to protect the foetus from xenobiotics in the maternal blood.
引用
收藏
页码：487 / 514
页数：27
相关论文
共 50 条
  • [21] EFFECT OF SEVERAL INHIBITORS ON METABOLISM AND TRANSFER OF GLUCOSE IN HUMAN TERM PLACENTA
    YAMADA, A
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 1967, 92 (03): : 229 - 242
  • [22] Transfer and metabolism of thyroid hormones in the placenta
    Kohrle, J
    ACTA MEDICA AUSTRIACA, 1997, 24 (04) : 138 - 143
  • [23] Methadone metabolism by human placenta
    Nanovskaya, TN
    Deshmukh, SV
    Nekhayeva, IA
    Zharikova, OL
    Hankins, GD
    Ahmed, MS
    BIOCHEMICAL PHARMACOLOGY, 2004, 68 (03) : 583 - 591
  • [24] Research on the metabolism of the human placenta
    Rech, W
    ZEITSCHRIFT FUR BIOLOGIE, 1924, 80 (3/4): : 231 - 238
  • [25] METABOLISM OF PREGNENOLONE BY HUMAN PLACENTA
    SINGH, KB
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1969, 104 (04) : 605 - &
  • [26] THE METABOLISM OF HUMAN PLACENTA INVITRO
    VILLEE, CA
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1953, 205 (01) : 113 - 123
  • [27] Bupropion metabolism by human placenta
    Wang, Xiaoming
    Abdelrahman, Doaa R.
    Zharikova, Olga L.
    Patrikeeva, Svetlana L.
    Hankins, Gary D. V.
    Ahmed, Mahmoud S.
    Nanovskaya, Tatiana N.
    BIOCHEMICAL PHARMACOLOGY, 2010, 79 (11) : 1684 - 1690
  • [28] CORTISOL METABOLISM IN HUMAN PLACENTA
    DORMER, RA
    FRANCE, JT
    NEW ZEALAND MEDICAL JOURNAL, 1973, 78 (501) : 364 - 364
  • [29] MALONATE METABOLISM IN HUMAN PLACENTA
    HOSOYA, N
    KAWADA, N
    JOURNAL OF BIOCHEMISTRY, 1958, 45 (05): : 363 - 365
  • [30] LIPID METABOLISM BY HUMAN PLACENTA
    ROUX, JF
    GREEN, R
    OBSTETRICS AND GYNECOLOGY, 1967, 29 (03): : 446 - &
12345