Effective synthesis of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines

被引：0
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作者：
Alexander S. Kulikov
Margarita A. Epishina
Leonid L. Fershtat
Nina N. Makhova
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
来源：
Chemistry of Heterocyclic Compounds | 2018年 / 54卷
关键词：
α-bromo ketones; hydrazinylthiadiazines; ortho esters; thiocarbohydrazide; 7; -1,2,4-triazolo[3,4-; ][1,3,4]thiadiazines; condensation;
D O I：
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学科分类号：
摘要：
A highly effective method for the preparation of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines was developed on the basis of condensation reaction between aryl(hetaryl) α-bromo ketones and commercially available thiocarbohydrazide, followed by treatment of the obtained 2-hydrazinyl-6H-1,3,4-thiadiazine hydrobromides with ortho esters in the presence of trifluoroacetic acid under mild conditions.
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页码：669 / 672
页数：3
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