Non-coding RNA networks in cancer

Non-coding RNAs (ncRNAs) participate in complex networks of interactions with other nucleic acids and proteins that often have wide-reaching effects on cell biology.The mechanisms by which ncRNAs work and/or function are routinely dysregulated in various cancers.Dysregulation of ncRNA interactions within cancer molecular pathways contributes to cancer and reveals important new targets for intervention.In cancer, disruptions in ncRNA networks often do not involve just mutations that cause a gross gain-of-function or loss-of-function of a given ncRNA but can also involve mutations that change the sequence and downstream targets of that ncRNA.