The IL-23–IL-17 axis in inflammatory arthritis

被引：0
|
作者：
Erik Lubberts
机构：
[1] Erasmus MC University Medical Center,Department of Rheumatology
来源：
Nature Reviews Rheumatology | 2015年 / 11卷
关键词：
D O I：
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学科分类号：
摘要：
The IL-23–IL-17 axis is critically involved in the development of autoimmunityTissue-specific IL-17A expression exacerbates tissue damage and disease chronicityThe roles of IL-23 and IL-17 at different stages in the development and progression of rheumatoid arthrits (RA) and spondyloarthritis needs further investigationGreater understanding of the role of the IL-23–IL-17 axis in RA as opposed to psoriatic arthritis and psoriasis is neededEarly combination therapy neutralizing both TNF activity and the IL-17/TH17 pathway might be a successful approach to achieving stable remission in patients with autoimmune disease and might even prevent disease development
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页码：415 / 429
页数：14
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