Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma

被引:0
|
作者
Phuong Thao Nguyen
Keishi Kanno
Quoc Thang Pham
Yuka Kikuchi
Masaki Kakimoto
Tomoki Kobayashi
Yuichiro Otani
Nobusuke Kishikawa
Mutsumi Miyauchi
Koji Arihiro
Masanori Ito
Susumu Tazuma
机构
[1] Hiroshima University Hospital,Department of General Internal Medicine
[2] Hiroshima University Graduate School of Biomedical and Health Sciences,Department of Molecular Pathology
[3] University of Medicine and Pharmacy at Ho Chi Minh City,Department of Pathology
[4] Hiroshima University Graduate School of Biomedical and Health Sciences,Department of Oral Maxillo
[5] Hiroshima University Hospital,Pathobiology
关键词
Deoxycholic acid; Cellular senescence; Hepatic stellate cells; Hepatocellular carcinoma; Epithelial mesenchymal transition; Senescence-associated secretory phenotype;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:3255 / 3268
页数:13
相关论文
共 50 条
  • [41] Bradykinin modulates the fibrogenic actions of hepatic stellate cells
    Sancho-Bru, P
    Bataller, R
    Colmenero, J
    Khurdayan, V
    Moreno, M
    Arroyo, V
    Ginès, P
    JOURNAL OF HEPATOLOGY, 2005, 42 : 122 - 122
  • [42] Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than ever
    Carloni, Vinicio
    Tu Vinh Luong
    Rombouts, Krista
    LIVER INTERNATIONAL, 2014, 34 (06) : 834 - 843
  • [43] Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies
    Ali, Esraa
    Trailin, Andriy
    Ambrozkiewicz, Filip
    Liska, Vaclav
    Hemminki, Kari
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (23)
  • [44] Correlation between the stromal activated hepatic stellate cells and angiogenesis in human hepatocellular carcinoma
    Lu, Yi
    Xu, Jianliang
    Zhou, Boxuan
    Lin, Nan
    Xu, Ruiyun
    Ling, Yunbiao
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017, 10 (02): : 1860 - 1865
  • [45] Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin
    Mogler, Carolin
    Koenig, Courtney
    Wieland, Matthias
    Runge, Anja
    Besemfelder, Eva
    Komljenovic, Dorde
    Longerich, Thomas
    Schirmacher, Peter
    Augustin, Hellmut G.
    EMBO MOLECULAR MEDICINE, 2017, 9 (06) : 741 - 749
  • [46] Characteristics of extracellular vesicles secreted from senescent hepatic stellate cells
    Miyazoe, Yuri
    Miuma, Satoshi
    Kanda, Yasuko
    Miyaaki, Hisamistu
    Taura, Naota
    Nakao, Kazuhiko
    Shibata, Hidetaka
    HEPATOLOGY, 2016, 64 : 255A - 255A
  • [47] Transport and killing mechanism of a novel camptothecin-deoxycholic acid derivate on hepatocellular carcinoma cells
    Li, Qingyong
    Liu, Tianyu
    Li, Yunchao
    Luo, Shuyue
    Zhu, Qiaochu
    Zhang, Li
    Zhao, Tengfei
    JOURNAL OF DRUG TARGETING, 2014, 22 (06) : 543 - 552
  • [48] Intratumoral Hepatic Stellate Cells as a Poor Prognostic Marker and a New Treatment Target for Hepatocellular Carcinoma
    Sun, Bin
    Zhang, Xiaofeng
    Cheng, Xianshuo
    Zhang, Yu
    Chen, Lei
    Shi, Lehua
    Liu, Zhenyu
    Qian, Haihua
    Wu, Mengchao
    Yin, Zhengfeng
    PLOS ONE, 2013, 8 (11):
  • [49] Hedgehog Signaling Activation in Hepatic Stellate Cells Promotes Angiogenesis and Vascular Mimicry in Hepatocellular Carcinoma
    Li, Wei
    Miao, Shuanlin
    Miao, Manyuan
    Li, Renshuan
    Cao, Xiaopeng
    Zhang, Kun
    Huang, Genzuan
    Fu, Bin
    CANCER INVESTIGATION, 2016, 34 (09) : 424 - 430
  • [50] Activated hepatic stellate cells promote angiogenesis in hepatocellular carcinoma by secreting angiopoietin-1
    Lin, Nan
    Meng, Lili
    Lin, Jizong
    Chen, Shuxian
    Zhang, Peng
    Chen, Qilong
    Lin, Yang
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2020, 121 (02) : 1441 - 1451