Regulation of chaperone activity in the endoplasmic reticulum

被引：0
|
作者：
Preissler S. [1 ]
机构：
[1] Cambridge Institute for Medical Research, University of Cambridge, The Keith Peters Building, Cambridge
来源：
BIOspektrum | 2020年 / 26卷 / 6期
关键词：
D O I：
10.1007/s12268-020-1455-6
中图分类号：
学科分类号：
摘要：
Maintenance of protein homeostasis depends on cellular stress response pathways that mediate adaptive changes in gene expression. In the endoplasmic reticulum additional mechanisms adjust the availability of the abundant Hsp70-type chaperone, BiP, during short-term fluctuations in the unfolded protein load. Here, recent insights into the regulation of BiP by incorporation into inactive oligomers and reversible AMPylation are discussed. © 2020, Die Autor.
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页码：612 / 614
页数：2
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