Provincial distribution of three HIV-1 resistant polymorphisms (CCR5-Δ32, CCR2-64I, and SDF1-3′ A) in China

被引：0

作者：

Junhua Xiao

Fang Hu

Hongyan Xu

Bing Su

Yueming Jiang

Jingchun Luo

Weiling Zhang

Jiazhen Tan

Li Jin

Daru Lu

机构：

[1] Fudan University,Institute of Genetics

[2] State Key Laboratory of Genetic Engineering,Human Genetics Center

[3] Suzhou Medical College,undefined

[4] UT-Houston,undefined

[5] Wuxi Contagious Diseases Hospital,undefined

[6] Shanghai Jing’an Hospital,undefined

来源：

Science in China Series C: Life Sciences | 2000年 / 43卷

关键词：

HIV-1; AIDS; PCR-RFLP;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

CCR5-Δ32, CCR2-64I, mutants in two chemokine receptors and SDF1-3′A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Δ 32 was observed. CCR2-64I and SDF1-3′ A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.

引用

页码：16 / 20

页数：4

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