Provincial distribution of three HIV-1 resistant polymorphisms (CCR5-Δ32, CCR2-64I, and SDF1-3′ A) in China

被引：0
|
作者：
Junhua Xiao
Fang Hu
Hongyan Xu
Bing Su
Yueming Jiang
Jingchun Luo
Weiling Zhang
Jiazhen Tan
Li Jin
Daru Lu
机构：
[1] Fudan University,Institute of Genetics
[2] State Key Laboratory of Genetic Engineering,Human Genetics Center
[3] Suzhou Medical College,undefined
[4] UT-Houston,undefined
[5] Wuxi Contagious Diseases Hospital,undefined
[6] Shanghai Jing’an Hospital,undefined
来源：
Science in China Series C: Life Sciences | 2000年 / 43卷
关键词：
HIV-1; AIDS; PCR-RFLP;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
CCR5-Δ32, CCR2-64I, mutants in two chemokine receptors and SDF1-3′A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Δ 32 was observed. CCR2-64I and SDF1-3′ A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.
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页码：16 / 20
页数：4
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