Mitochondrial InjuryLessons from the Fialuridine Trial

被引：0
|
作者：
Pieter Honkoop
Hans R. Scholte
Robert A. de Man
Solko W. Schalm
机构：
[1] Erasmus University Hospital,Department of Internal Medicine II (Section Hepatology)
[2] Erasmus University Hospital,Department of Biochemistry
[3] Erasmus University Hospital,Department of Internal Medicine II (Ca 326)
来源：
Drug Safety | 1997年 / 17卷
关键词：
Chronic Hepatitis; Lamivudine; Zidovudine; Lactic Acidosis; Nucleoside Analogue;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Fialuridine is an antiviral agent with potent activity against hepatitis B virus replication in vitro and in vivo. In a phase II study, 7 of 15 patients experienced severe toxicity due to the drug after 9 to 13 weeks of treatment. Adverse effects included nausea, vomiting and painful paraesthesia; subsequently, hepatic failure, pancreatitis, neuropathy, myopathy and lactic acidosis developed, probably due to multisystem mitochondrial toxicity.
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页码：1 / 7
页数：6
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