Application of statistically-based experimental designs for the optimization of nisin production from whey

被引：0
|
作者：
Chuanbin Liu
Yan Liu
Wei Liao
Zhiyou Wen
Shulin Chen
机构：
[1] Washington State University,Department of Biological Systems Engineering
来源：
Biotechnology Letters | 2003年 / 25卷
关键词：
experimental design; fermentation; nisin; optimization; whey;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Statistically-based experimental designs were applied for the optimization of nisin production by Lactococcus lactis in a whey-based medium. Yeast extract, KH2PO4, and MgSO4 were identified to have significant effects on nisin biosynthesis by a Plackett–Burman design. These three significant factors were subsequently optimized using central composite design, and the optimal conditions were determined to be 12.067 g l−1 for yeast extract, 0.569 g l−1 for KH2PO4, and 0.572 g l−1 for MgSO4. The validity of the optimal conditions was verified by a separate experiment.
引用
收藏
页码：877 / 882
页数：5
相关论文
共 50 条
  • [31] Optimization of siderophores production from fluorescent pseudomonads using statistical experimental designs
    Abo-Zaid, Gaber Attia
    Abdullah, Ahmed Salah
    Soliman, Nadia Abdel-Mohsen
    El-Sharouny, Ebaa Ebrihim
    Sabry, Soraya Abdel-Fattah
    BIOSCIENCE RESEARCH, 2018, 15 (04): : 3040 - 3051
  • [32] Stimulation of nisin production from whey by a mixed culture of Lactococcus lactis and Saccharomyces cerevisiae
    Liu, Chuanbin
    Hu, Bo
    Liu, Yan
    Chen, Shulin
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2006, 131 (1-3) : 751 - 761
  • [33] Optimization of microbial transglutaminase production using experimental designs
    M. Junqua
    R. Duran
    C. Gancet
    P. Goulas
    Applied Microbiology and Biotechnology, 1997, 48 : 730 - 734
  • [34] Optimization of microbial transglutaminase production using experimental designs
    Junqua, M
    Duran, R
    Gancet, C
    Goulas, P
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1997, 48 (06) : 730 - 734
  • [35] Nisin production from Lactococcus lactis ATCC 7962 using supplemented whey permeate
    Flôres, SH
    Alegre, RM
    BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2001, 34 : 103 - 107
  • [36] Stimulation of Nisin production from whey by a mixed culture of Lactococcus lactis and Saccharomyces cerevisiae
    Chuanbin Liu
    Bo Hu
    Yan Liu
    Shulin Chen
    Applied Biochemistry and Biotechnology, 2006, 131 : 751 - 761
  • [37] Modeling and optimization of cutinase production by recombinant Escherichia coli based on statistical experimental designs
    Li, Jianghua
    Liu, Long
    Wu, Jing
    Sun, Jun
    Du, Guocheng
    Chen, Jian
    Tao, Wenyi
    KOREAN JOURNAL OF CHEMICAL ENGINEERING, 2010, 27 (04) : 1233 - 1238
  • [38] Modeling and optimization of cutinase production by recombinant Escherichia coli based on statistical experimental designs
    Jianghua Li
    Long Liu
    Jing Wu
    Jun Sun
    Guocheng Du
    Jian Chen
    Wenyi Tao
    Korean Journal of Chemical Engineering, 2010, 27 : 1233 - 1238
  • [39] Optimization of Nisin Production by Lactococcus lactis UQ2 Using Supplemented Whey as Alternative Culture Medium
    Gonzalez-Toledo, S. Y.
    Dominguez-Dominguez, J.
    Garcia-Almendarez, B. E.
    Prado-Barragan, L. A.
    Regalado-Gonzalez, C.
    JOURNAL OF FOOD SCIENCE, 2010, 75 (06) : M347 - M353
  • [40] Utilization of condensed distillers solubles as nutrient supplement for production of nisin and lactic acid from whey
    Chuanbin Liu
    Bo Hu
    Shulin Chen
    Richard W. Glass
    Applied Biochemistry and Biotechnology, 2007, 137-140 : 875 - 884
12345