Diterpenoids isolated from the Samoan marine sponge Chelonaplysilla sp. inhibit Mycobacterium tuberculosis growth

被引：0
|
作者：
Josiane A. Monteiro de Oliveira
David E. Williams
Shilah Bonnett
James Johnson
Tanya Parish
Raymond J. Andersen
机构：
[1] University of British Columbia,Departments of Chemistry and Earth, Ocean & Atmospheric Sciences
[2] Infectious Disease Research Institute,TB Discovery Research
[3] Seattle Children’s Hospital,Seattle Children’s Research Institute
来源：
The Journal of Antibiotics | 2020年 / 73卷
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摘要：
Crude extracts of the marine sponge Chelonaplysilla sp. collected in Samoa, that were obtained from the NCI Open Repository (NCS 21903), inhibited Mycobacterium tuberculosis growth. Assay-guided fractionation of the extract led to the isolation and structural elucidation of the known diterpenoid macfarlandin D (1) and three new diterpenoids macfarlandins F (2), G (3), and H (4). Macfarlandin D (1) exhibited potent antimicrobial activity against M. tuberculosis with an MIC of 1.2 ± 0.4 µg mL−1. Macfarlandins F (2), G (3), and H (4) exhibited significantly weaker antitubercular activities, revealing SAR for the macfarlandin antitubercular pharmacophore. The structures of compounds 2, 3, and 4 were elucidated via detailed analysis of NMR and MS data.
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页码：568 / 573
页数：5
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