AROMATIC ALKALOIDS FROM THE MARINE SPONGE CHELONAPLYSILLA SP

被引：54
|
作者：
BOBZIN, SC [1 ]
FAULKNER, DJ [1 ]
机构：
[1] UNIV CALIF SAN DIEGO,SCRIPPS INST OCEANOG,LA JOLLA,CA 92093
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 14期
关键词：
D O I：
10.1021/jo00014a015
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four novel alkaloids derived from tryptophan and tyrosine subunits have been isolated from the marine sponge Chelonaplysilla sp. collected from a marine lake in Palau. The structures of chelonin A (3), chelonin B (4), bromochelonin B (5), and chelonin C (6) were determined by interpretation of spectral data and chemical conversions. Chelonin A (3) and C (6) are the first natural products incorporating a 2,6-disubstituted morpholine ring. Chelonin A (3), chelonin B (4), and bromochelonin B (5) exhibited antimicrobial activity against Bacillus subtilis, while chelonin A (3) showed in vivo antiinflammatory activity.
引用
收藏
页码：4403 / 4407
页数：5
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