ANTIPYRETIC, ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF CERTAIN γ-OXOBUTANOIC ACID DERIVATIVES

被引：0

作者：

Khaled A. Abouzid

Khairia M. Youssef

Amany A. E. Ahmed

Hanaa Hussain Al-Zuhair

机构：

[1] Ain Shams University,Department of Pharaceutical Chemistry

[2] King Saud University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy

[3] King Saud University,Department of Pharmacology, Faculty of Pharmacy

来源：

Medicinal Chemistry Research | 2005年 / 14卷

关键词：

Celecoxib; Acid Derivative; Open Ring; Chemical Entity; Fenbufen;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Three chemical entities were synthesized as analogs of fenbufen as well as open ring analog of suldinac and celecoxib. The new compounds were evaluated for antipyretic, antinociceptive and anti-inflammatory activities. Among these compounds, 6-benzo[1,3]dioxol-5-yl-4-oxo-hex-5-enoic acid (3) was the most active one.

引用

页码：26 / 39

页数：13

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